{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:02:47Z","timestamp":1753876967464,"version":"3.41.2"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The course of COVID-19 patients may be complicated by thromboembolic events. We report on a 48-year-old female COVID-19 patient who underwent surgical removal of a large intracardiac thrombus. As per our centre protocol, critically ill COVID-19 patients are anticoagulated by the direct thrombin inhibitor Argatroban with close monitoring of anti-IIa activity. An intra-atrial thrombus formation fixed in a patent foramen ovale but also large mobile portions in both atria was diagnosed 4 days after weaning and removal of the jugular and femoral extracorporeal membrane oxygenation cannulas. The thrombus was removed surgically via median sternotomy and on cardiopulmonary bypass. The thrombus had a bizarre appearance with several finger-like appendices, and histological analysis revealed a mixed picture of acute and chronic thrombus portions. This case highlights the risk of life-threatening thrombus formation in COVID-19 patients despite therapeutic thrombin inhibition.<\/jats:p>","DOI":"10.1093\/icvts\/ivac077","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T20:12:28Z","timestamp":1647461548000},"source":"Crossref","is-referenced-by-count":2,"title":["Large thrombus in transit in a COVID-19 patient"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9669-7372","authenticated-orcid":false,"given":"Sabine","family":"Bleiziffer","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, University Hospital Ruhr-University Bochum , Bad Oeynhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Zabel","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Nuclear Medicine and Molecular Imaging, Heart and Diabetes Center North Rhine-Westphalia Bochum, University Hospital of the Ruhr-University , Bad Oeynhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan F","family":"Gummert","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, University Hospital Ruhr-University Bochum , Bad Oeynhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-8737","authenticated-orcid":false,"given":"Marcus-Andr\u00e9","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, University Hospital Ruhr-University Bochum , Bad Oeynhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"2022072010380159300_ivac077-B1","doi-asserted-by":"crossref","first-page":"e524","DOI":"10.1016\/S2352-3026(21)00105-8","article-title":"COVID-19-associated coagulopathy and antithrombotic agents-lessons after 1 year","volume":"8","author":"Leentjens","year":"2021","journal-title":"Lancet Haematol"},{"key":"2022072010380159300_ivac077-B2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10557-020-07066-x","article-title":"Thrombin inhibition by argatroban: potential therapeutic benefits in COVID-19","volume":"35","author":"Aliter","year":"2021","journal-title":"Cardiovasc Drugs Ther"},{"key":"2022072010380159300_ivac077-B3","doi-asserted-by":"crossref","first-page":"e663","DOI":"10.1097\/CCM.0000000000004971","article-title":"A comparison of thrombosis and hemorrhage rates in patients with severe respiratory failure due to 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Res"},{"key":"2022072010380159300_ivac077-B6","doi-asserted-by":"crossref","first-page":"e409","DOI":"10.1016\/j.athoracsur.2020.04.005","article-title":"Severe acute proximal pulmonary embolism and COVID-19: word of caution","volume":"110","author":"Fabre","year":"2020","journal-title":"Ann Thorac Surg"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/35\/2\/ivac077\/45029438\/ivac077.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/35\/2\/ivac077\/45029438\/ivac077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T22:39:26Z","timestamp":1700347166000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivac077\/6563055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,4]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,7,9]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivac077","relation":{},"ISSN":["1569-9293","1569-9285"],"issn-type":[{"type":"print","value":"1569-9293"},{"type":"electronic","value":"1569-9285"}],"subject":[],"published-other":{"date-parts":[[2022,8,1]]},"published":{"date-parts":[[2022,4,4]]},"article-number":"ivac077"}}