{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:53:27Z","timestamp":1790610807444,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Research Fund of Landspitali University Hospital"},{"name":"Research Fund of University of Iceland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Surgical revascularization is an established indication for patients with advanced coronary artery disease and reduced left ventricular ejection fraction (LVEF). Long-term outcomes for these patients are not well-defined. We studied the long-term outcomes of patients with ischaemic cardiomyopathy who underwent surgical revascularization in a well-defined nationwide cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MATERIALS AND METHODS<\/jats:title>\n                  <jats:p>A retrospective study on 2005 patients that underwent isolated coronary artery bypass grafting in Iceland between 2000 and 2016. Patients were categorized into two groups based on their preoperative LVEF; LVEF \u226435% (n\u2009=\u2009146, median LVEF 30%) and LVEF &amp;gt;35% (n\u2009=\u20091859, median LVEF 60%). Demographics and major adverse cardiac and cerebrovascular events were compared between groups along with cardiac-specific and overall survival. The median follow-up was 7.6\u2009years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Demographics were similar in both groups regarding age, gender and most cardiovascular risk factors. However, patients with LVEF \u226435% more often had diabetes, renal insufficiency, chronic obstructive pulmonary disease and a previous history of myocardial infarction. Thirty-day mortality was 4 times higher (8% vs 2%, P\u2009&amp;lt;\u20090.001) in the LVEF \u226435%-group compared to controls. Overall survival was significantly lower in the LVEF \u226435%-group compared to controls, at 1 year (87% vs. 98%, P &amp;lt; 0.001) and 5 years (69% vs. 91%, P &amp;lt; 0.001). In multivariable analysis LVEF \u226435% was linked to inferior survival with an adjusted hazard ratio of 2.0 (95%-CI 1.5 - 2.6, p&amp;lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>A good long-term outcome after coronary artery bypass grafting can be expected for patients with reduced LVEF, however, their survival is still significantly inferior to patients with normal ventricular function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivac095","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T19:20:13Z","timestamp":1650396013000},"source":"Crossref","is-referenced-by-count":3,"title":["Long-term outcome of surgical revascularization in patients with reduced left ventricular ejection fraction\u2014a population-based cohort study"],"prefix":"10.1093","volume":"35","author":[{"given":"Helga B","family":"Brynjarsdottir","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Landspitali University Hospital , Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arni","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Landspitali University Hospital , Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1948-5696","authenticated-orcid":false,"given":"Alexandra A","family":"Heimisdottir","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Landspitali University Hospital , Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunna R\u00fan","family":"Heidarsdottir","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Landspitali University Hospital , Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Jeppsson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg, Sweden"},{"name":"Department of Cardiothoracic Surgery, Sahlgrenska University Hospital , Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin I","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Landspitali University Hospital , Reykjavik, Iceland"},{"name":"Faculty of Medicine, University of Iceland , Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Gudbjartsson","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Landspitali University Hospital , Reykjavik, Iceland"},{"name":"Faculty of Medicine, University of Iceland , Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"2022082714192535700_ivac095-B1","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics-2021 update: a report from the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"2022082714192535700_ivac095-B2","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.116.003255","article-title":"Survival benefits of invasive versus conservative strategies in heart failure in patients with reduced ejection fraction and coronary artery disease: a meta-analysis","volume":"10","author":"Wolff","year":"2017","journal-title":"Circ Heart Fail"},{"key":"2022082714192535700_ivac095-B3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1056\/NEJM197709222971201","article-title":"Treatment of chronic stable angina. 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