{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:45:45Z","timestamp":1768812345417,"version":"3.49.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Even after transplantation of favourable donor lungs, some recipients require prolonged weaning from mechanical ventilation, indicating a poor prognosis. We investigated the effects of prolonged mechanical ventilation (PMV) for &amp;gt;14\u2009days on the recovery and survival of patients who underwent cadaveric lung transplantation in relation to their physical traits.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We retrospectively reviewed patients who underwent cadaveric lung transplantation (age \u226515\u2009years) at a single centre between April 2015 and December 2020 and classified them into PMV and non-PMV groups (&amp;gt;14 and \u226414\u2009days of mechanical ventilation postoperatively, respectively). The factors predicting PMV comprised clinical factors (e.g. marginal donor) and physical features, namely flat chest, narrow fourth intercostal space (length, &amp;lt;5\u2009mm), mediastinal shift, thoracic mediastinal-occupying ratio (TMOR) &amp;gt;40% and sarcopenia, according to the logistic regression analysis. The log-rank test was used to examine the association between TMOR &amp;gt;40% and 3-year prognosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The PMV group comprised 17 (33%) of 51 recipients. Multivariable logistic analysis showed that the TMOR &amp;gt;40% (odds ratio, 7.3; 95% confidence interval, 1.3\u201340.1; P = 0.023) was an independent preoperative predictive factor for PMV postoperatively. Stepwise analysis revealed intraoperative extracorporeal membrane oxygenation and reoperation as postoperative predictive factors in addition to TMOR &amp;gt;40%. Recipients with TMOR &amp;gt;40% had significantly worse 3-year survival than other recipients (71.2% vs 100.0%, respectively; P = 0.008).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Recipients with a TMOR &amp;gt;40% may be long-term ventilator dependent and have a poor prognosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivac106","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T11:23:02Z","timestamp":1650367382000},"source":"Crossref","is-referenced-by-count":2,"title":["Thoracic mediastinal-occupying ratio predicts recovery and prognosis after lung transplantation"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0982-2222","authenticated-orcid":false,"given":"Nobuyuki","family":"Yoshiyasu","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, The University of Tokyo Hospital , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The University of Tokyo Hospital , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yasui","sequence":"additional","affiliation":[{"name":"Rehabilitation Center, The University of Tokyo Hospital , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Takami","sequence":"additional","affiliation":[{"name":"Graduate School of Life and Environmental Sciences, Kyoto Prefectural University , Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Clinical Research Promotion Center, The University of Tokyo Hospital , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Konoeda","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The University of Tokyo Hospital , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1174-0816","authenticated-orcid":false,"given":"Jun","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The University of Tokyo Hospital , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"2022082714201568000_ivac106-B1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.healun.2020.07.009","article-title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult lung transplantation report-2020; focus on deceased donor characteristics","volume":"39","author":"Chambers","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"2022082714201568000_ivac106-B2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.21037\/jovs.2020.03.06","article-title":"Current status of lung transplantation in Japan\u2014report from Japanese lung transplant registry","volume":"7","author":"Okada","year":"2021","journal-title":"J Vis Surg"},{"key":"2022082714201568000_ivac106-B3","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s00595-019-01782-0","article-title":"Impact of chronic lung allograft dysfunction, especially restrictive allograft syndrome, on the survival after living-donor lobar lung transplantation compared with cadaveric lung transplantation in adults: a single-center experience","volume":"49","author":"Sugimoto","year":"2019","journal-title":"Surg Today"},{"key":"2022082714201568000_ivac106-B4","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1111\/ajt.16626","article-title":"Pediatric living-donor lobar lung transplantation in postpneumonectomy-like anatomy caused by pulmonary hypoplasia with congenital diaphragmatic hernia","volume":"21","author":"Yoshiyasu","year":"2021","journal-title":"Am J Transplant"},{"key":"2022082714201568000_ivac106-B5","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/ejcts\/ezy248","article-title":"Impact of flat chest on cadaveric lung transplantation: postoperative pulmonary function and survival","volume":"55","author":"Miyahara","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022082714201568000_ivac106-B6","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0022-3468(87)80585-7","article-title":"Use of CT scans in selection of patients for pectus excavatum surgery: a preliminary report","volume":"22","author":"Haller","year":"1987","journal-title":"J Pediatr Surg"},{"key":"2022082714201568000_ivac106-B7","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1007\/s00414-021-02593-0","article-title":"Evaluation of the mediastinal-thoracic volume ratio on postmortem computed tomography","volume":"135","author":"Chatzaraki","year":"2021","journal-title":"Int J Legal Med"},{"key":"2022082714201568000_ivac106-B8","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s11748-019-01250-z","article-title":"The impact of surgical chest wall damage caused by classic thoracotomy on pulmonary function and morphology","volume":"68","author":"Yoshiyasu","year":"2020","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"2022082714201568000_ivac106-B9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Consensus update on sarcopenia diagnosis and treatment","volume":"21","author":"Chen","year":"2020","journal-title":"J Am Med Dir Assoc"},{"key":"2022082714201568000_ivac106-B10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1067\/mtc.2002.120345","article-title":"Marginal donor lungs: a reassessment","volume":"123","author":"Pierre","year":"2002","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022082714201568000_ivac106-B11","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/ajt.16495","article-title":"OPTN\/SRTR 2019 Annual data report: lung","volume":"21","author":"Valapour","year":"2021","journal-title":"Am J Transplant"},{"key":"2022082714201568000_ivac106-B12","doi-asserted-by":"crossref","first-page":"S631","DOI":"10.21037\/jtd.2016.06.38","article-title":"Current status and problems of lung transplantation in Japan","volume":"8","author":"Date","year":"2016","journal-title":"J Thorac Dis"},{"key":"2022082714201568000_ivac106-B13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12890-021-01442-5","article-title":"Recovery of physical function in lung transplant recipients with sarcopenia","volume":"21","author":"Nikkuni","year":"2021","journal-title":"B.M.C. Pulm Med"},{"key":"2022082714201568000_ivac106-B14","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.healun.2019.08.004","article-title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-sixth adult heart transplantation report-2019; focus theme: donor and recipient size match","volume":"38","author":"Khush","year":"2019","journal-title":"J Heart Lung Transplant"},{"key":"2022082714201568000_ivac106-B15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/JCM.S13564","article-title":"Association between lung function and metabolic syndrome independent of insulin in Japanese men and women","volume":"5","author":"Yamamoto","year":"2014","journal-title":"Jpn Clin Med"},{"key":"2022082714201568000_ivac106-B16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ppul.22536","article-title":"Development of reference equations for spirometry in Japanese children aged 6\u201318 years","volume":"48","author":"Takase","year":"2013","journal-title":"Pediatr Pulmonol"},{"key":"2022082714201568000_ivac106-B17","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/tri.13491","article-title":"Risk factors for early bleeding complications after lung transplantation\u2014a retrospective cohort study","volume":"32","author":"Adelmann","year":"2019","journal-title":"Transpl Int"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivac106\/43406282\/ivac106.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/35\/3\/ivac106\/45597009\/ivac106.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/35\/3\/ivac106\/45597009\/ivac106.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T14:20:48Z","timestamp":1661610048000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivac106\/6571812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,29]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,8,3]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivac106","relation":{},"ISSN":["1569-9293","1569-9285"],"issn-type":[{"value":"1569-9293","type":"print"},{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,1]]},"published":{"date-parts":[[2022,4,29]]},"article-number":"ivac106"}}