{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:18:07Z","timestamp":1772252287415,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Our goal was to analyse adverse events in adolescent and adult patients with the Berlin Heart EXCOR and to assess the outcome of a subsequent heart transplant (HTX).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>From 2006 to 2020, a total of 58 patients (12\u201364\u2009years old) received a biventricular assist device (BIVAD) at our institution and were included in this study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The causes of biventricular heart failure were nonischaemic cardiomyopathy (62.1%), ischaemic cardiomyopathy (22.4%) and myocarditis (15.5%). The median INTERMACS score was I (I\u2014III). The median age was 49\u2009years (interquartile range, 34\u201355\u2009years), and 82.8% were male. Causes of death were multiorgan failure (25.0%), septic shock (17.9%), cerebral haemorrhage (14.3%), bleeding (14.3%) and embolic events (14.3%). Major bleeding was more frequent in the patients who died while on BIVADs (60.7 vs 6.7%, P\u2009&amp;lt;\u20090.001). Wound infections were more prevalent in HTX recipients (n\u2009=\u200921, 70.0%). After BIVAD thrombosis, 104 chamber exchanges were performed in 28 patients (48.3%). HTXs were performed in 52.6% of the patients after a BIVAD support time of 316\u2009\u00b1\u2009240\u2009days. The mean time to follow-up of 30 HTX recipients was 1722\u2009\u00b1\u20091368\u2009days. One-, 6- and 12-month survival after an HTX were 96.7%, 90.0% and 76.7%, respectively. Long-term survival after 5 and 10\u2009years was 69.7%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Pump thrombosis, infections and bleeding after receiving a BIVAD did not preclude a successful HTX. Although only 50% of patients with BIVADs were successfully given a transplant, long-term survival after an HTX in patients with BIVAD was noninferior compared to that of other recipients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivac107","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T11:16:59Z","timestamp":1649935019000},"source":"Crossref","is-referenced-by-count":6,"title":["Long-term paracorporeal pulsatile mechanical circulatory support in adolescent and adult patients"],"prefix":"10.1093","volume":"35","author":[{"given":"Jamila","family":"Kremer","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Heidelberg , Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"El-Dor","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Heidelberg , Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiebke","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Heidelberg , Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Tochtermann","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Heidelberg , Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Warnecke","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Heidelberg , Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Karck","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Heidelberg , Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjang","family":"Ruhparwar","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic and Cardiovascular Surgery, Essen University Hospital , Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Lassia","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Heidelberg , Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"2022082714195135800_ivac107-B1","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1056\/NEJMoa0909938","article-title":"Advanced heart failure treated with continuous-flow left ventricular assist device","volume":"361","author":"Slaughter","year":"2009","journal-title":"N Engl J Med"},{"key":"2022082714195135800_ivac107-B2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/MAT.0000000000000645","article-title":"Durable biventricular support using right atrial placement of the heartware hvad","volume":"64","author":"Tran","year":"2018","journal-title":"Asaio J"},{"key":"2022082714195135800_ivac107-B3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.healun.2020.12.006","article-title":"The results of a single-center experience with heartmate 3 in a biventricular configuration","volume":"40","author":"McGiffin","year":"2021","journal-title":"J Heart Lung Transplant"},{"key":"2022082714195135800_ivac107-B4","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.healun.2020.08.006","article-title":"International experience using a durable, centrifugal-flow ventricular assist device for biventricular support","volume":"39","author":"Marasco","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"2022082714195135800_ivac107-B5","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.healun.2015.10.003","article-title":"Seventh intermacs annual report: 15,000 patients and counting","volume":"34","author":"Kirklin","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"2022082714195135800_ivac107-B6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/ejcts\/ezz173","article-title":"Results of primary biventricular support: an analysis of data from the euromacs registry","volume":"56","author":"Vierecke","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022082714195135800_ivac107-B7","doi-asserted-by":"crossref","first-page":"101477","DOI":"10.1016\/j.trim.2021.101477","article-title":"The effect of paracorporeal pulsatile biventricular assist devices on allosensitization in adults: a comparison with left ventricular assist devices","volume":"69","author":"Chaidaroglou","year":"2021","journal-title":"Transpl Immunol"},{"key":"2022082714195135800_ivac107-B8","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezab547","article-title":"Bridging patients in cardiogenic shock with a paracorporeal pulsatile biventricular assist device to heart transplantation-a single-centre experience","author":"Michel","year":"2022","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022082714195135800_ivac107-B9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00392-017-1200-4","article-title":"Successful support of biventricular heart failure patients by new excor((r)) adult pumps with bileaflet valves: a prospective study","volume":"107","author":"Schmack","year":"2018","journal-title":"Clin Res Cardiol"},{"key":"2022082714195135800_ivac107-B10","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1002\/ehf2.12888","article-title":"Temporary right ventricular circulatory support following right ventricular infarction: results of a groin-free approach","volume":"7","author":"Kremer","year":"2020","journal-title":"ESC Heart Fail"},{"key":"2022082714195135800_ivac107-B11","doi-asserted-by":"crossref","first-page":"e12936","DOI":"10.1111\/tid.12936","article-title":"Infections in patients after berlin heart((r)) excor assist device implantation","volume":"20","author":"Munoz","year":"2018","journal-title":"Transpl Infect Dis"},{"key":"2022082714195135800_ivac107-B12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/1089253219898985","article-title":"Heart transplantation after ventricular assist device therapy: benefits, risks, and outcomes","volume":"24","author":"Pal","year":"2020","journal-title":"Semin Cardiothorac Vasc Anesth"},{"key":"2022082714195135800_ivac107-B13","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.healun.2017.07.005","article-title":"Eighth annual intermacs report: special focus on framing the impact of adverse events","volume":"36","author":"Kirklin","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"2022082714195135800_ivac107-B14","doi-asserted-by":"crossref","first-page":"S179","DOI":"10.1161\/CIRCULATIONAHA.110.011502","article-title":"Biventricular circulatory support with two miniaturized implantable assist devices","volume":"124","author":"Krabatsch","year":"2011","journal-title":"Circulation"},{"key":"2022082714195135800_ivac107-B15","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.healun.2015.12.001","article-title":"Long-term biventricular heartware ventricular assist device support\u2013case series of right atrial and right ventricular implantation outcomes","volume":"35","author":"Shehab","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"2022082714195135800_ivac107-B16","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/jocs.12823","article-title":"Comparison of total artificial heart and biventricular assist device support as bridge-to-transplantation","volume":"31","author":"Cheng","year":"2016","journal-title":"J Card Surg"},{"key":"2022082714195135800_ivac107-B17","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.healun.2015.10.018","article-title":"Right ventricular assist device results in worse post-transplant survival","volume":"35","author":"Taghavi","year":"2016","journal-title":"J Heart Lung Transplant"},{"issue":"Suppl s1","key":"2022082714195135800_ivac107-B18","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/ajt.15676","article-title":"Optn\/srtr 2018 annual data report: heart","volume":"20","author":"Colvin","year":"2020","journal-title":"Am J Transplant"},{"key":"2022082714195135800_ivac107-B19","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.healun.2014.10.005","article-title":"Late right heart failure during support with continuous-flow left ventricular assist devices adversely affects post-transplant outcome","volume":"34","author":"Takeda","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"2022082714195135800_ivac107-B20","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.athoracsur.2017.08.019","article-title":"Biventricular support with intracorporeal, continuous flow, centrifugal ventricular assist devices","volume":"105","author":"Arabia","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"2022082714195135800_ivac107-B21","doi-asserted-by":"crossref","first-page":"e578","DOI":"10.1161\/CIR.0000000000000560","article-title":"Evaluation and management of right-sided heart failure: a scientific statement from the american heart association","volume":"137","author":"Konstam","year":"2018","journal-title":"Circulation"},{"key":"2022082714195135800_ivac107-B22","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.jtcvs.2020.04.163","article-title":"Durable circulatory support with a paracorporeal device as an option for pediatric and adult heart failure patients","volume":"161","author":"Bartfay","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022082714195135800_ivac107-B23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s10047-021-01275-3","article-title":"Extracorporeal membrane oxygenation as a bridge to durable left ventricular assist device implantation in intermacs-1 patients","volume":"25","author":"Lamba","year":"2022","journal-title":"J Artif Organs"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivac107\/43704924\/ivac107.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/35\/3\/ivac107\/45596960\/ivac107.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/35\/3\/ivac107\/45596960\/ivac107.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T14:20:19Z","timestamp":1661610019000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivac107\/6582577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,9]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,8,3]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivac107","relation":{},"ISSN":["1569-9293","1569-9285"],"issn-type":[{"value":"1569-9293","type":"print"},{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,1]]},"published":{"date-parts":[[2022,5,9]]},"article-number":"ivac107"}}