{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:47:02Z","timestamp":1788799622624,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The aim of this study was to evaluate the impact of changing the sizing strategy in aortic valve replacement using the Perceval sutureless prosthesis on haemodynamic outcomes and postoperative pacemaker implantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Retrospective analysis of patients implanted with the Perceval valve between 2007 and 2019 was performed by comparing patients implanted before the modification of sizing strategy (OLD group) and after (NEW group). The outcome parameters evaluated were the implanted prosthesis size, haemodynamical profile and postoperative pacemaker implantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The entire patient cohort (784 patients) consisted of 52% female patients, with a mean age of 78.53 [standard deviation (SD): 5.8] years and a mean EuroSCORE II of 6.3 (range 0.7\u201376). In 55.5% of cases, surgery was combined. The NEW cohort had more male patients (54.6% vs 43.4%) (P\u2009=\u20090.002). Mean implanted valve size, corrected for body surface area, was significantly lower in the NEW cohort (13.1, SD: 1.4 vs 13.5, SD: 1.4\u2009mm\/m2, P\u2009&amp;lt;\u20090.001). The 30-day mortality was 3.4%. Peak and mean transvalvular gradients at discharge were significantly lower in the NEW versus OLD groups: 24.4\u2009mmHg (SD: 9.2) versus 28.4\u2009mmHg (SD: 10.3) (P\u2009&amp;lt;\u20090.001) and 13.6\u2009mmHg (SD: 5.3) versus 15.5\u2009mmHg (SD: 6.0) (P\u2009&amp;lt;\u20090.001). The mean effective opening area and the indexed effective opening area, respectively, increased from 1.5 cm2 (SD: 0.5) and 0.85 cm2\/m2 (SD: 0.27) in the OLD group to 1.7 cm2 (SD: 0.5) and 0.93 cm2\/m2 (SD: 0.30) in the NEW group (P\u2009&amp;lt;\u20090.001). No difference was found in paravalvular leakage \u22651\/4. Centrovalvular leakage \u22651\/4 significantly decreased from 18% to 7.9% (P\u2009&amp;lt;\u20090.001). With the new sizing, the new postoperative pacemaker implantation rate decreased significantly from 11% to 6.1% (P\u2009=\u20090.016).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Correct sizing of sutureless aortic valves is crucial to obtain the best possible haemodynamics and avoid complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivac157","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T13:31:51Z","timestamp":1654954311000},"source":"Crossref","is-referenced-by-count":28,"title":["Avoiding oversizing in sutureless valves leads to lower transvalvular gradients and less permanent pacemaker implants postoperatively"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5728-7338","authenticated-orcid":false,"given":"Delphine","family":"Szecel","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences\u2014Cardiac Surgery, Katholieke Universiteit Leuven , Leuven, Belgium"},{"name":"Department of Cardiovascular Surgery, CHU de Li\u00e8ge , Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Lamberigts","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences\u2014Cardiac Surgery, Katholieke Universiteit Leuven , Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Rega","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences\u2014Cardiac Surgery, Katholieke Universiteit Leuven , Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-1706","authenticated-orcid":false,"given":"Peter","family":"Verbrugghe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences\u2014Cardiac Surgery, Katholieke Universiteit Leuven , Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Dubois","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences\u2014Cardiac Surgery, Katholieke Universiteit Leuven , Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-293X","authenticated-orcid":false,"given":"Bart","family":"Meuris","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences\u2014Cardiac Surgery, Katholieke Universiteit Leuven , Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,11]]},"reference":[{"key":"2022071107565073000_ivac157-B1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/ejcts\/ezz055","article-title":"Minimally invasive aortic valve replacement with sutureless and rapid deployment valves: a report from an international registry (Sutureless and Rapid Deployment International Registry)","volume":"56","author":"Berretta","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022071107565073000_ivac157-B2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jtcvs.2020.11.162","article-title":"Sutureless versus conventional bioprostheses for aortic valve replacement in severe symptomatic aortic valve stenosis","volume":"161","author":"Fischlein","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022071107565073000_ivac157-B3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.athoracsur.2017.12.044","article-title":"Increased gradients after aortic valve replacement with the Perceval valve: the role of oversizing","volume":"106","author":"Cerillo","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"2022071107565073000_ivac157-B4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jtcvs.2016.09.035","article-title":"The risk of oversizing with sutureless bioprosthesis in small aortic annulus","volume":"153","author":"Baert","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022071107565073000_ivac157-B5","first-page":"808","article-title":"Permanent pacemaker implantation and paravalvular leak rates following sutureless aortic valve operations","volume":"33","author":"Lazkani","year":"2018","journal-title":"J Card 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