{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:40:43Z","timestamp":1791463243858,"version":"4.3.4"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Thymomectomy is gaining consensus over complete thymectomy in early-stage thymoma without myasthenia gravis. This is due both to the difficulty of establishing prospective and randomized controlled studies and to the lack of well-defined selection criteria. This bicentric, retrospective propensity score-matched study aims at comparing oncological outcomes, measured in terms of overall survival and thymoma-related survival, in patients undergoing either thymomectomy or complete thymectomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We retrospectively analysed medical records of patients with clinical early-stage (I and II) thymoma undergoing thymomectomy or complete thymectomy. Exclusion criteria were the presence of myasthenia gravis, clinical advanced tumours and thymic carcinoma. A propensity score-matching analysis was applied to reduce potential preoperative selection biases such as comorbidity (Charlson score), tumour maximal diameter and surgical approach (open versus minimal). All variables were dichotomized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 255 patients were enrolled from 2 different Hospitals, 126 underwent complete thymectomy and 129 a thymomectomy. Disease-free and thymoma-related survivals showed a 5-year rate of 87.7% and 96.0% and a 10-year rate of 82.2% and 91.9%, respectively. Propensity score-matching analysis selected a total of 176 patients equally divided between the 2 groups. No difference was found for both disease-free (P\u2009=\u20090.11) and thymoma-related (P\u2009=\u20090.37) survival in the 2 groups of resection. Multivariable Cox regression analysis showed that histology (P\u2009&amp;lt;\u20090.001), residual disease (P\u2009&amp;lt;\u20090.001) and adjuvant chemotherapy (P\u2009&amp;lt;\u20090.001) were the only predictors of shorter disease-free survival. Whereas there was no evidence to confirm that disease-free and thymoma-related survivals were influenced by resection extent.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Thymomectomy is an adequate surgical resection for non-myasthenic thymoma, achieving disease-free and thymoma-related survivals comparable to those after complete thymectomy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivac167","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T13:42:42Z","timestamp":1655732562000},"source":"Crossref","is-referenced-by-count":12,"title":["Thymomectomy versus complete thymectomy in early-stage non-myasthenic thymomas: a multicentric propensity score-matched study"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9091-6797","authenticated-orcid":false,"given":"Emanuele","family":"Voulaz","sequence":"first","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Department of Thoracic Surgery , Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Perroni","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Thoracic Surgery, Tor Vergata University Polyclinic , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Russo","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Thoracic Surgery, Tor Vergata University Polyclinic , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandro","family":"Patirelis","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Thoracic Surgery, Tor Vergata University Polyclinic , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8394-2719","authenticated-orcid":false,"given":"Giuseppe","family":"Mangiameli","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Department of Thoracic Surgery , Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6997-360X","authenticated-orcid":false,"given":"Marco","family":"Alloisio","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Department of Thoracic Surgery , Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8947-3175","authenticated-orcid":false,"given":"Vincenzo","family":"Ambrogi","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Thoracic Surgery, Tor Vergata University Polyclinic , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"2022062907510754600_ivac167-B1","doi-asserted-by":"crossref","first-page":"v40","DOI":"10.1093\/annonc\/mdv277","article-title":"Thymic epithelial tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"26","author":"Girard","year":"2015","journal-title":"Ann. 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