{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:09:52Z","timestamp":1787504992713,"version":"build-2736575974"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>The aim of this retrospective study was to assess the early- and long-term outcomes following the use of cryopreserved allografts in aortic valve endocarditis with peri-annular abscess formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>From 2001 to 2021, 110 consecutive patients with active infective endocarditis and peri-annular abscess, underwent a cryopreserved allograft root replacement. In 100 patients (91%), the operation was performed &amp;lt;48\u2009h after admission due to refractory heart failure and or septic shock. In 95 patients (86.4%), a redo operation was performed due to a prosthetic valve endocarditis. Preoperatively, 12 patients were dialysis-dependent and 30 patients suffered from a recent stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The 30-day mortality was 18% (20 patients). Freedom from reintervention was 98.3% (standard deviation: 1.7) at 1\u2009year and 83.3% (standard deviation: 8.5) at 10\u2009years. Four patients required a redo operation. Three patients did develop re-endocarditis. Freedom from re-endocarditis was 95% after 17\u2009years of follow-up. Preoperative dialysis dependency (odds ratio: 22.75, 95% confidence interval: 4.79\u2013108.14, P\u2009&amp;lt;\u20090.001), ejection fraction under 30% (odds ratio: 17.91, 95% confidence interval: 3.27\u201398.01, P\u2009&amp;lt;\u20090.001) and stroke within 14\u2009days prior to operation (odds ratio: 5.21, 95% confidence interval: 1.28\u201321.2, P\u2009=\u20090.021) were incremental factors associated with the 30-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>In aortic root endocarditis with abscesses formation, cryopreserved allografts exhibit excellent clinical performance with a low rate of reinfection and reintervention, which make its use as valve replacement a very desirable option. Dialysis dependency, ejection fraction under 30% and recent stroke have the highest impact on the 30-day mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivac188","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T10:47:17Z","timestamp":1656931637000},"source":"Crossref","is-referenced-by-count":11,"title":["A 20-year experience with cryopreserved allografts as the valve replacement of choice in aortic root reconstruction for destructive endocarditis with abscess formation"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5868-5397","authenticated-orcid":false,"given":"Afram","family":"Yousif","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Braunschweig Clinic , Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaldoun","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Braunschweig Clinic , Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Anssar","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Braunschweig Clinic , Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Harringer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Braunschweig Clinic , Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5583-039X","authenticated-orcid":false,"given":"Aschraf","family":"El-Essawi","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, University of G\u00f6ttingen , G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Braunschweig Clinic , Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"2022070912371487100_ivac188-B1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.athoracsur.2019.10.029","article-title":"Incidence and surgical outcomes of patients with native and prosthetic aortic valve endocarditis","volume":"110","author":"Luehr","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"2022070912371487100_ivac188-B2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/ejcts\/ezv138","article-title":"Early and late outcomes of complex aortic root surgery in patients with aortic root abscesses","volume":"49","author":"Leontyev","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022070912371487100_ivac188-B3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S1010-7940(96)01020-2","article-title":"Long-term results of surgery for acute infective endocarditis","volume":"11","author":"d'Udekem","year":"1997","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022070912371487100_ivac188-B4","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0022-5223(19)35075-5","article-title":"Aortic valve replacement for active infectious endocarditis in 108 patients. 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