{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:58:56Z","timestamp":1762642736217,"version":"3.41.2"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Helin\u00e4 W\u00e4h\u00e4\/Alfred Kordelin"},{"name":"Finnish Foundation for Paediatric Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The aim of this study was to assess predictors of BP and hypertension and relations between BP and LV mass in a population-based retrospective study of repaired isolated coarctation of aorta.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We collected follow-up data until 2018 of 284\/304 (93%) patients with coarctation treated by surgery (n\u2009=\u2009235) or balloon angioplasty\/stent (n\u2009=\u200937\/12) in our unit 2000\u20132012. Systolic hypertension was defined as systolic BP (SBP) z-score \u2265+2 standard deviation (SD) or regular use of BP medication. LV hypertrophy was defined as LV mass z-score \u2265+2 SD or LV mass index g\/m2.7 \u226595th percentile.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The median (25\u201375th percentiles) follow-up time and age at follow-up were 9.7\u2009years (6.9\u201313.2) and 11.8\u2009years (7.9\u201316.0), respectively. Age at first procedure (P\u2009=\u20090.011) and systolic arm-leg-gradient (P\u2009=\u20090.007) were positively and transverse arch (P\u2009=\u20090.007) and isthmus diameter (P\u2009=\u20090.001) z-scores at follow-up were negatively associated with SBP z-score adjusted for age at follow-up and need for reintervention for coarctation. Systolic hypertension was present in 53\/284 (18.7%) and related with increasing age at first procedure (median 33.2 vs 0.6\u2009months; P\u2009&amp;lt;\u20090.001) and arm-leg-gradient at follow-up (mean \u00b1 SD, \u22120.3\u2009\u00b1\u200914.6 vs \u22126.4\u2009\u00b1\u200911.6\u2009mmHg; P\u2009=\u20090.047) adjusted for reintervention for coarctation and age at follow-up. LV hypertrophy was present in 20\/227 (9.3%) and related with SBP z-score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Higher SBP and hypertension in repaired coarctation of aorta are related with increasing age at first procedure and arm-leg-gradient at follow-up. Transverse arch and isthmus diameters at follow-up are inversely related with SBP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivac212","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T19:58:07Z","timestamp":1660075087000},"source":"Crossref","is-referenced-by-count":5,"title":["Predictors of blood pressure and hypertension long-term after treatment of isolated coarctation of the aorta in children\u2014a population-based study"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-9841","authenticated-orcid":false,"given":"Mari K","family":"Ylinen","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, New Children\u2019s hospital, University of Helsinki and Helsinki University Hospital , Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaana I","family":"Pihkala","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, New Children\u2019s hospital, University of Helsinki and Helsinki University Hospital , Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka T","family":"Salminen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, New Children\u2019s hospital, University of Helsinki and Helsinki University Hospital , Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisto","family":"Sarkola","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, New Children\u2019s hospital, University of Helsinki and Helsinki University Hospital , Helsinki, Finland"},{"name":"Minerva Foundation Institute for Medical Research , Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"2022081614400821300_ivac212-B1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jtcvs.2007.04.027","article-title":"Coarctation Long-term Assessment (COALA): significance of arterial hypertension in a cohort of 404 patients up to 27 years after surgical repair of isolated coarctation of the aorta, even in the absence of restenosis and prosthetic material","volume":"134","author":"Hager","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022081614400821300_ivac212-B2","doi-asserted-by":"crossref","first-page":"e012056","DOI":"10.1161\/JAHA.119.012056","article-title":"Coronary artery disease in adults with coarctation of aorta: incidence, risk factors, and outcomes","volume":"8","author":"Egbe","year":"2019","journal-title":"J Am Heart 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