{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:05:46Z","timestamp":1793325946652,"version":"4.5.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy and safety of intraoperative cone-beam computed tomography-guided video-assisted thoracoscopic surgery wedge resection of impalpable small pulmonary nodules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This was a single-centre phase 2 trial conducted between April 2018 and March 2019. Peripheral small pulmonary nodules, defined as either ground-glass opacity-dominant (&amp;gt;50%) nodules measuring \u22643\u2009cm in diameter (ground-glass opacity-dominant type) or nodules measuring \u22642\u2009cm in diameter located deeper than the nodule diameter from the visceral pleura (deep solid type), were eligible for resection using a cone-beam computed tomography-guided thoracoscopic manner. The primary end-point was macroscopic complete resection, and secondary end-points were: nodule extraction rate, operation time, localization time, marking accuracy, microscopic complete resection and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Twenty-two nodules, in 9 men and 11 women with a mean age of 64.3\u2009years, were visualized and resected. The nodules were located in the right upper, middle and lower lobes in 3, 1 and 5 patients, respectively, and in the left upper and lower lobes in 5 and 8 patients, respectively. Seven nodules were ground-glass opacity-dominant types, and 15 were deep solid types. Cone-beam computed tomography could clearly image all nodules. The mean time for localization was 17.4\u2009min. The mean operation time was 110.7\u2009min. Macroscopic complete resection was accomplished in 21 nodules (95.5%). Microscopic complete resection was achieved in all nodules (100%). Postoperative air leakage and bleeding were observed in 1 patient (5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Cone-beam computed tomography might be a safe and useful guide for video-assisted thoracoscopic surgery wedge resection of impalpable peripheral pulmonary nodules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Date and number of IRB approval<\/jats:title>\n                    <jats:p>15 November 2017, 381.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration number<\/jats:title>\n                    <jats:p>UMIN 000030388.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivac236","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T09:58:53Z","timestamp":1663149533000},"source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of intraoperative cone-beam CT-guided localization of small pulmonary nodules"],"prefix":"10.1093","volume":"35","author":[{"given":"Taisuke","family":"Kaiho","sequence":"first","affiliation":[{"name":"Department of General Thoracic Surgery, Chiba University Graduate School of Medicine , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8983-433X","authenticated-orcid":false,"given":"Hidemi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Chiba University Graduate School of Medicine , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Chiba University Graduate School of Medicine , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Chiba University Graduate School of Medicine , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Chiba University Graduate School of Medicine , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Sakairi","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Chiba University Graduate School of Medicine , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Radiology, Chiba University Hospital , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3959-9343","authenticated-orcid":false,"given":"Yuki","family":"Shiko","sequence":"additional","affiliation":[{"name":"Biostatistics Section, Clinical Research Center, Chiba University Hospital , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7474-7647","authenticated-orcid":false,"given":"Yohei","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Center for Preventive Medicine Sciences, Chiba University , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Chiba University Graduate School of Medicine , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"2022092120530216800_ivac236-B1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"Aberle","year":"2011","journal-title":"N Engl J Med"},{"key":"2022092120530216800_ivac236-B2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1911793","article-title":"Reduced lung-cancer mortality with volume CT screening in a randomized trial","volume":"382","author":"de Koning","year":"2020","journal-title":"N Engl J Med"},{"key":"2022092120530216800_ivac236-B3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/jjco\/hyw148","article-title":"Limited resection for early-stage non-small cell lung cancer as function-preserving radical surgery: a review","volume":"47","author":"Aokage","year":"2017","journal-title":"Jpn J Clin Oncol"},{"key":"2022092120530216800_ivac236-B4","doi-asserted-by":"crossref","first-page":"8561","DOI":"10.1200\/JCO.2017.35.15_suppl.8561","article-title":"A nonrandomized confirmatory phase III study of sublobar surgical resection for peripheral ground glass opacity dominant lung cancer defined with thoracic thin-section computed tomography (JCOG0804\/WJOG4507L)","volume":"35","author":"Suzuki","year":"2017","journal-title":"J Clin Oncol"},{"key":"2022092120530216800_ivac236-B5","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jtcvs.2017.03.140","article-title":"A novel minimally invasive near-infrared thoracoscopic localization technique of small pulmonary nodules: a phase I feasibility trial","volume":"154","author":"Ujiie","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022092120530216800_ivac236-B6","doi-asserted-by":"crossref","first-page":"778","DOI":"10.2214\/AJR.19.21175","article-title":"Intraoperative percutaneous microcoil localization of small peripheral pulmonary nodules using cone-beam CT in a hybrid operating room","volume":"213","author":"Lempel","year":"2019","journal-title":"AJR Am J Roentgenol"},{"key":"2022092120530216800_ivac236-B7","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1007\/s00464-019-06883-y","article-title":"Image-guided thoracoscopic lung resection using a dual-marker localization technique in a hybrid operating room","volume":"33","author":"Chao","year":"2019","journal-title":"Surg Endosc"},{"key":"2022092120530216800_ivac236-B8","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/1759-7714.12983","article-title":"Simultaneous cone beam computed tomography-guided bronchoscopic marking and video-assisted thoracoscopic wedge resection in a hybrid operating room","volume":"10","author":"Anayama","year":"2019","journal-title":"Thorac Cancer"},{"key":"2022092120530216800_ivac236-B9","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.jtcvs.2016.12.044","article-title":"Intraoperative electromagnetic navigational bronchoscopic localization of small, deep, or subsolid pulmonary nodules","volume":"153","author":"Abbas","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022092120530216800_ivac236-B10","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.jtcvs.2018.05.122","article-title":"Effect of virtual-assisted lung mapping in acquisition of surgical margins in sublobar lung resection","volume":"156","author":"Sato","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022092120530216800_ivac236-B11","first-page":"S319","article-title":"Hybrid theatre and alternative localization techniques in conventional and single-port video-assisted thoracoscopic surgery","volume":"8","author":"Zhao","year":"2016","journal-title":"J Thorac Dis"},{"key":"2022092120530216800_ivac236-B12","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jtcvs.2005.09.019","article-title":"Fluoroscopy-assisted thoracoscopic resection of pulmonary nodules after computed tomography-guided bronchoscopic metallic coil marking","volume":"131","author":"Miyoshi","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022092120530216800_ivac236-B13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jtcvs.2014.08.055","article-title":"Preoperative computed tomography-guided microcoil localization of small peripheral pulmonary nodules: a prospective randomized controlled trial","volume":"149","author":"Finley","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022092120530216800_ivac236-B14","doi-asserted-by":"crossref","first-page":"E59","DOI":"10.21037\/jtd.2017.12.04","article-title":"Systemic air embolism after computed tomography-guided hook wire localization: two case report and literature review","volume":"10","author":"Yi","year":"2018","journal-title":"J Thorac Dis"},{"key":"2022092120530216800_ivac236-B15","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jtcvs.2009.02.002","article-title":"Intraoperative ultrasonographic localization of pulmonary ground-glass opacities","volume":"138","author":"Kondo","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022092120530216800_ivac236-B16","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.athoracsur.2016.08.031","article-title":"Evaluation of a new ultrasound thoracoscope for localization of lung nodules in ex vivo human lungs","volume":"103","author":"Ujiie","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"2022092120530216800_ivac236-B17","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1183\/09031936.00136408","article-title":"Small studies: strengths and limitations","volume":"32","author":"Hackshaw","year":"2008","journal-title":"Eur Respir J"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivac236\/45841472\/ivac236.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/35\/4\/ivac236\/45960497\/ivac236.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/35\/4\/ivac236\/45960497\/ivac236.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T17:18:05Z","timestamp":1663780685000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivac236\/6697889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,9]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,9,9]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivac236","relation":{},"ISSN":["1569-9285"],"issn-type":[{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,10,1]]},"published":{"date-parts":[[2022,9,9]]},"article-number":"ivac236"}}