{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:43:26Z","timestamp":1784641406534,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Primary thoracic synovial sarcoma (SS) is a rare, high-grade, malignancy. Involvement of vital organs is frequent and may decrease the benefits of surgical resection. We reviewed our practice at a highly experienced thoracic-surgery centre to assess early- and long-term outcomes after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We conducted a retrospective, observational, single-centre study of patients undergoing curative-intent surgery for primary thoracic SS between 1 January 2000 and 31 January 2021 as part of a multidisciplinary management. We assessed demographics, medical history, histopathology and follow-up information.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>We enrolled 20 patients (13 males) with a median age of 40\u2009years old and a median tumour size of 11\u2009cm. Neoadjuvant chemotherapy was administered to 13 patients. Surgery consisted in extrapleural pneumonectomy (n\u2009=\u20097), extrapleural lobectomy (n\u2009=\u20095), chest wall resection (n\u2009=\u20094) or tumour resection (n\u2009=\u20094). R0 resection was achieved in 16 (80%) patients. Adjuvant therapy was given to 13 patients. 6 patients developed postoperative complications. The median hospital stay was 11.5\u2009days. Overall survival at 2 and 5\u2009years was 51% and 22%, respectively; median overall survival was 25\u2009months and median disease-free survival was 8.5\u2009months. Relapses occurred in 15 patients. By univariate analysis, incomplete resection was the only significant predictor of survival (P\u2009=\u20090.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Primary thoracic SS is an aggressive disease. Surgery included in a multimodal treatment may contribute to achieving a good outcome, providing that an R0 resection is obtained. Given the considerable technical challenges of surgery, patient selection and referral to an experienced centre are crucial to minimize morbidity and mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivac238","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T14:16:31Z","timestamp":1662473791000},"source":"Crossref","is-referenced-by-count":6,"title":["Feasibility and long-term outcomes of surgery for primary thoracic synovial sarcoma"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8474-5418","authenticated-orcid":false,"given":"Sara","family":"Pieropan","sequence":"first","affiliation":[{"name":"Department of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital-GHPSJ, Paris-Saclay University , Le Plessis-Robinson, 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