{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:35:25Z","timestamp":1788550525642,"version":"build-2803163510"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Smart Medical Care of Zhongshan Hospital","award":["2020ZHZS01"],"award-info":[{"award-number":["2020ZHZS01"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20DZ2261200"],"award-info":[{"award-number":["20DZ2261200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070085"],"award-info":[{"award-number":["82070085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research Project of Zhongshan Hospital","award":["2020ZSLC38"],"award-info":[{"award-number":["2020ZSLC38"]}]},{"name":"Clinical Research Project of Zhongshan Hospital","award":["2020ZSLC27"],"award-info":[{"award-number":["2020ZSLC27"]}]},{"name":"Research Project of Shanghai Municipal Health Commission","award":["20214Y0136"],"award-info":[{"award-number":["20214Y0136"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>This study assessed the impact of early postoperative organ dysfunction (EPOD) on in-hospital mortality of patients with type A aortic dissection (TAAD) after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Patients with TAAD who underwent surgical repair requiring deep hypothermic circulatory arrest from January 2020 to December 2021 were included. The Sequential Organ Failure Assessment (SOFA) score was calculated for 3 days postoperatively to stratify the severity of organ dysfunction. Patients with the SOFA of 0\u20134, 5\u20138 or &amp;gt;8 were defined as mild, moderate or severe EPOD. The primary outcome was in-hospital mortality, and a composite secondary outcome was defined as in-hospital death or any major complications. Kaplan\u2013Meier curves were used to compare survival probability. The area under the receiver operating characteristic curve and calibration plots were used to evaluate the predictive power and overall performance of SOFA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of the 368 patients, 5 patients (3%) with moderate EPOD and 33 patients (23%) with severe EPOD died. No patient died with mild EPOD. The areas under the receiver operating characteristic curve of SOFA for predicting mortality and the composite outcome were 0.85 (0.81\u20130.88) and 0.81 (0.77\u20130.85) on postoperative day 1. Each point of postoperative day 1 SOFA score corresponded to an odds ratio of 1.65 (1.42\u20131.92) for mortality. Of the 6 components of the SOFA system, only coagulation (2.34 [1.32\u20134.13]), cardiovascular (1.47 [1.04\u20132.08]), central nervous system (1.96 [1.36\u20132.82]) and renal (1.67 [1.04\u20132.70]) functions were associated with the higher risk of mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>EPOD stratified by the SOFA score was associated with a higher risk of death and predicted the clinical outcomes of patients with TAAD with good accuracy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivac266","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T13:47:57Z","timestamp":1667051277000},"source":"Crossref","is-referenced-by-count":17,"title":["Early postoperative organ dysfunction is highly associated with the mortality risk of patients with type A aortic dissection"],"prefix":"10.1093","volume":"35","author":[{"given":"Ming-Hao","family":"Luo","sequence":"first","affiliation":[{"name":"Shanghai Medical College, Fudan University , Shanghai, China"},{"name":"Department of Critical Care Medicine, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Chao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Zhongshan Hospital, Fudan University , Shanghai, China"},{"name":"Department of Critical Care Medicine, Pan Long People\u2019s Hospital , Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Kun","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Medical College, Fudan University , Shanghai, China"},{"name":"Department of Critical Care Medicine, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Xin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Wei","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Zhongshan Hospital, Fudan University , Shanghai, 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