{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:22:38Z","timestamp":1787008958622,"version":"build-2736575974"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Cytoreductive surgery and hyperthermic intrathoracic chemotherapy (HITOC) is effective on survival for patients with pleural metastatic thymic tumours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Multicentre, retrospective analysis of patients with stage IVa thymic tumours treated with surgical resection and HITOC. Primary end point was overall survival, secondary end points were recurrence-\/progression-free survival and morbidity\/mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of n\u2009=\u200958 patients (thymoma, n\u2009=\u200942; thymic carcinoma, n\u2009=\u200915; atypical carcinoid of the thymus, n\u2009=\u20091) were included, who had primary pleural metastases (n\u2009=\u200950; 86%) or pleural recurrence (n\u2009=\u20098; 14%). Lung-preserving resection (n\u2009=\u200956; 97%) was the preferred approach. Macroscopically complete tumour resection was achieved in n\u2009=\u200949 patients (85%). HITOC was performed with cisplatin alone (n\u2009=\u200938; 66%) or in combination with doxorubicin (n\u2009=\u200920; 34%). Almost half of the patients (n\u2009=\u200928; 48%) received high-dose cisplatin &amp;gt; 125\u2009mg\/m2 body surface area. Surgical revision was required in 8 (14%) patients. In-hospital mortality rate was 2%. During follow-up, tumour recurrence\/progression was evident in n\u2009=\u200931 (53%) patients. Median follow-up time was 59\u2009months. The 1-, 3- and 5-year survival rates were 95%, 83% and 77%, respectively. Recurrence\/progression-free survival rates were 89%, 54% and 44%, respectively. Patients with thymoma had significantly better survival compared to patients with thymic carcinoma (P-value \u22640.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Promising survival rates in patients with pleural metastatic stage IVa in thymoma (94%) and even in thymic carcinoma (41%) were achieved. Surgical resection and HITOC is safe and effective for treatment of patients with pleural metastatic thymic tumours stage IVa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivad032","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T10:35:24Z","timestamp":1676025324000},"source":"Crossref","is-referenced-by-count":5,"title":["Surgical cytoreduction and hyperthermic intrathoracic chemotherapy for thymic tumours with pleural spread is effective on survival: results from the multicentre German hyperthermic intrathoracic chemotherapy study"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2365-4803","authenticated-orcid":false,"given":"Michael","family":"Ried","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, University Hospital Regensburg , Regensburg, 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