{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:29:58Z","timestamp":1760898598869,"version":"3.41.2"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The aim of this study was to evaluate the association between vasoactive\u2013inotropic score (VIS), calculated in the 24\u2009h after heart transplantation, and post-transplant mortality and morbidity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>This was an observational single-centre retrospective study. Patients admitted to surgical intensive care unit after transplantation, between January 2015 and December 2018, were reviewed consecutively. VISmax was calculated as dopamine+ dobutamine+ 100 \u00d7 epinephrine + 100 \u00d7 norepinephrine + 50 \u00d7 levosimendan + 10 \u00d7 milrinone (all in \u00b5g\/kg\/min) + 10\u00a0000 \u00d7 vasopressin (units\/kg\/min), using the maximum dosing rates of vasoactive and inotropic medications in the 24\u2009h after intensive care unit admission. The primary outcome was mortality at 1 year post-transplant. The secondary outcomes included length of stay, duration of mechanical ventilation and inotropic support and the occurrence of septic shock, ventilator-associated pneumonia, bloodstream infection or renal replacement therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 151 patients underwent heart transplantation and admitted to intensive care unit. The median VISmax was 39.2 (interquartile range = 19.4\u201383.0). VISmax was independently associated with 1-year post-transplant mortality, as well as recipient age [hazard ratio (HR) = 1.004, P-value = 0.013], recipient gender (female to male: hazard ratio = 2.23, P-value = 0.047) and combined transplantation (hazard ratio = 2.85, P-value = 0.048). There was a significant association between VISmax and duration of mechanical ventilation (P-value &amp;lt; 0.001), length of stay (P-value = 0.002), duration of infused inotropes (P-value &amp;lt; 0.001), occurrence of bloodstream infections, septic shocks, ventilation-acquired pneumonia and renal replacement therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>VISmax calculated during the first 24\u2009h after postoperative intensive care unit admission in transplanted patients is independently associated with 1-year mortality. In addition, length of stay, duration of mechanical ventilation and infused inotropes increased with increasing VISmax.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivad055","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T14:28:38Z","timestamp":1681741718000},"source":"Crossref","is-referenced-by-count":6,"title":["Association between vasoactive\u2013inotropic score, morbidity and mortality after heart transplantation"],"prefix":"10.1093","volume":"36","author":[{"given":"Joanna","family":"Tohme","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Cardiology Institute, Sorbonne University, GRC29, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mickael","family":"Lescroart","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Cardiology Institute, Sorbonne University, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00e9mie","family":"Guillemin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Cardiology Institute, Sorbonne University, GRC29, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Orer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Cardiology Institute, Sorbonne University, GRC29, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Dureau","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Cardiology Institute, Sorbonne University, GRC29, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaida","family":"Varnous","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Cardiology Institute, Sorbonne University, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Leprince","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Cardiology Institute, Sorbonne University, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Coutance","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Cardiology Institute, Sorbonne University, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8990-4705","authenticated-orcid":false,"given":"Adrien","family":"Bougl\u00e9","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Cardiology Institute, Sorbonne University, GRC29, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"2023042101173323900_ivad055-B1","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the 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