{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:30:21Z","timestamp":1770895821920,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,19]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A best-evidence topic was written according to a structured protocol. The question addressed was the following: in patient undergoing lung transplantation, are lungs from donors of age &amp;gt;60\u2009years old (yo) associated with equivalent outcomes\u2014including primary graft dysfunction, respiratory function and survival\u2014than lungs from donors \u226460yo? Altogether, &amp;gt;200 papers were found using the reported search, of which 12 represented the best evidence to answer the clinical question. The authors, journals, dates, country of publication, patients group studied, study type, relevant outcomes, and results of these papers were tabulated. Amongst the 12 papers reviewed, survival results were different depending on whether donor age was analysed raw or adjusted for recipients\u2019 age and initial diagnosis. Indeed, recipients with interstitial lung disease (ILD), pulmonary hypertension or cystic fibrosis (CF) had significantly inferior overall survival when receiving grafts from older donors. When older grafts are allocated to younger donors, a significant decrease in survival has been noticed in the case of single lung transplantation. In addition, 3 papers showed worse results regarding peak forced expiratory volume in 1\u2009second (FEV1) in patients receiving older organs, and 4 showed comparable primary graft dysfunction incidence rates. We conclude that when carefully assessed and allocated to the recipient who could benefit most from the transplant (e.g., a patient with a diagnosis of chronic obstructive pulmonary disease (COPD), who would not require a prolonged cardiopulmonary bypass (CPB)), lung grafts from donors of &amp;gt;60yo offer comparable results to younger donors.<\/jats:p>","DOI":"10.1093\/icvts\/ivad111","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T13:49:30Z","timestamp":1688824170000},"source":"Crossref","is-referenced-by-count":3,"title":["Donors in lung transplantation: does age matter?"],"prefix":"10.1093","volume":"37","author":[{"given":"Charlotte","family":"Ponte","sequence":"first","affiliation":[{"name":"H\u00f4pitaux Universitaire de Strasbourg, Service de chirurgie thoracique\u2014Nouvel H\u00f4pital Civil , Strasbourg, France"},{"name":"INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS , Strasbourg, France"},{"name":"Universit\u00e9 de Strasbourg, Facult\u00e9 de m\u00e9decine et pharmacie , Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Alkhatiri","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaire de Strasbourg, Service de chirurgie thoracique\u2014Nouvel H\u00f4pital Civil , Strasbourg, France"},{"name":"Universit\u00e9 de Strasbourg, Facult\u00e9 de m\u00e9decine et pharmacie , Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Olland","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaire de Strasbourg, Service de chirurgie thoracique\u2014Nouvel H\u00f4pital Civil , Strasbourg, France"},{"name":"INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS , Strasbourg, France"},{"name":"Universit\u00e9 de Strasbourg, Facult\u00e9 de m\u00e9decine et pharmacie , Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5915-5512","authenticated-orcid":false,"given":"Pierre-Emmanuel","family":"Falcoz","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaire de Strasbourg, Service de chirurgie thoracique\u2014Nouvel H\u00f4pital Civil , Strasbourg, France"},{"name":"INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS , Strasbourg, France"},{"name":"Universit\u00e9 de Strasbourg, Facult\u00e9 de m\u00e9decine et pharmacie , Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,7,8]]},"reference":[{"key":"2023072313114131100_ivad111-B1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1569-9293(03)00191-9","article-title":"Towards evidence-based medicine in cardiothoracic surgery: best 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