{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:06:10Z","timestamp":1793325970594,"version":"4.5.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Medical and Health Research","award":["2018KY171"],"award-info":[{"award-number":["2018KY171"]}]},{"name":"Zhejiang Medical and Health Research","award":["2018KY818"],"award-info":[{"award-number":["2018KY818"]}]},{"name":"Experimental Animal Project of Zhejiang Science and Technology Agency","award":["2018C37104"],"award-info":[{"award-number":["2018C37104"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>This study aimed to investigate whether adding glue injection to three-dimensional computed tomography bronchography and angiography (3D-CTBA) has extra benefits to facilitate anatomical segmentectomy for pulmonary nodules.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We conducted a randomized controlled trial. The patients undergoing thoracoscopic segmentectomy assisted with 3D-CTBA simulation were enrolled. Then, they were divided into the 3D-CTBA group and the glue-labelling group who received additional computed tomography-guided percutaneous glue (2-octyl cyanoacrylate) injection to label the nodules. The primary outcome was the resection rate of the nodules, and the secondary measures included the operation time, complications and thorax drainage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 173 patients were randomized into the 3D-CTBA group (89 patients) and glue-labelling group (84 patients) between January 2018 and March 2019. Before the segmentectomy, the patients using glue labelling recorded 5 (6.0%) cases of pneumothorax, 2 (2.4%) cases of haemothorax and 1 (1.2%) case of severe chest pain. All the surgical procedure was performed fluently and safely. The resection rate of the nodules was 100% in both groups. Furthermore, these patients demonstrated similar operation time [(141.5\u2009\u00b1\u200941.9) vs (142.1\u2009\u00b1\u200938.9) min], estimated blood loss [(111.3\u2009\u00b1\u200974.0) vs (106.0\u2009\u00b1\u200963.8) ml], duration of chest tube duration [(5.1\u2009\u00b1\u20093.0) vs (5.0\u2009\u00b1\u20093.5) days] and total drainage volume [(872.3\u2009\u00b1\u2009643.1) vs (826.7\u2009\u00b1\u2009806.0) ml], with a P-value of &amp;gt;0.05 respectively. In addition, 6 (7.1%) patients in the glue-labelling group and 6 (6.7%) patients in the 3D-CTBA group reported air leakage (&amp;gt;5\u2009days) and chylothorax.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Noninvasive 3D-CTBA alone is probably sufficient to facilitate anatomical segmentectomy. The additional invasive glue labelling could be avoided in selected patients who undergo intentional segmentectomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration<\/jats:title>\n                  <jats:p>The trial was registered under the Chinese Clinical Trial Registry (ChiCTR). Identifier: ChiCTR1800018293, https:\/\/www.chictr.org.cn\/showproj.html?proj=29345.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivad156","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T16:57:08Z","timestamp":1695142628000},"source":"Crossref","is-referenced-by-count":2,"title":["Noninvasive 3D-CT simulation versus glue injection to localize small pulmonary nodules prior to anatomical segmentectomy: a randomized controlled trial"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2407-2212","authenticated-orcid":false,"given":"Linhai","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital , Shaoxing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8183-1687","authenticated-orcid":false,"given":"Wenbin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Xuzhou Central Hospital , Xuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisherjon","family":"Oblokulov","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital , Shaoxing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital , Shaoxing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital , Shaoxing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital , Shaoxing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanlin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital , Shaoxing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhupeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital , Shaoxing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangmao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital , Shaoxing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5860-8500","authenticated-orcid":false,"given":"Chu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital , Shaoxing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7431-5986","authenticated-orcid":false,"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Xuzhou Central Hospital , Xuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"2024022314222830400_ivad156-B1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1001\/jama.2021.24287","article-title":"Evaluating the patient with a pulmonary nodule: a review","volume":"327","author":"Mazzone","year":"2022","journal-title":"JAMA"},{"key":"2024022314222830400_ivad156-B2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.chest.2016.09.017","article-title":"Comparative effectiveness and safety of preoperative lung localization for pulmonary nodules: a systematic review and 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