{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:02:10Z","timestamp":1753876930672,"version":"3.41.2"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K10729","20K09124","20K05227"],"award-info":[{"award-number":["17K10729","20K09124","20K05227"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The use of bone wax (BW) is controversial for sternal haemostasis because it increases the risk of wound infection and inhibits bone healing. We developed new waxy bone haemostatic agents made from biodegradable polymers containing peptides and evaluated them using rabbit models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We designed 2 types of waxy bone haemostatic agents: peptide wax (PW) and non-peptide wax (NPW), which used poly(\u03b5-caprolactone)-based biodegradable polymers with or without an osteogenesis-enhancing peptide, respectively. Rabbits were randomly divided into 4 groups based on treatment with BW, NPW, PW or no treatment. In a tibial defect model, the bleeding amount was measured and bone healing was evaluated by micro-computed tomography over 16\u2009weeks. Bone healing in a median sternotomy model was assessed for 2\u2009weeks using X-ray, micro-computed tomography, histological examination and flexural strength testing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The textures of PW and NPW (n\u2009=\u200912 each) were similar to that of BW and achieved a comparable degree of haemostasis. The crevice area of the sternal fracture line in the BW group was significantly larger than that in other groups (n\u2009=\u200910 each). The PW group demonstrated the strongest sternal flexural strength (n\u2009=\u200910), with complete tibial healing at 16\u2009weeks. No groups exhibited wound infection, including osteomyelitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Waxy biodegradable haemostatic agents showed satisfactory results in haemostasis and bone healing in rabbit models and may be an effective alternative to BW.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivad170","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T13:05:03Z","timestamp":1699275903000},"source":"Crossref","is-referenced-by-count":0,"title":["Development of novel waxy bone haemostatic agents composed of biodegradable polymers with osteogenic-enhancing peptides in rabbit models"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9051-4202","authenticated-orcid":false,"given":"Tsukasa","family":"Ohno","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Tokai National Higher Education and Research System , Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Suenaga","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Tokai National Higher Education and Research System , Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aika","family":"Yamawaki-Ogata","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Tokai National Higher Education and Research System , Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Kanie","sequence":"additional","affiliation":[{"name":"Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Tokai National Higher Education and Research System , Nagoya, Japan"},{"name":"Department of Biotechnology and Chemistry, Kindai University, Higashi-Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Tokai National Higher Education and Research System , Nagoya, Japan"},{"name":"Division of Micro-Nano Mechatronics, Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Tokai National Higher Education and Research System , Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Uto","sequence":"additional","affiliation":[{"name":"Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science (NIMS) , Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Ebara","sequence":"additional","affiliation":[{"name":"Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science (NIMS) , Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0164-6108","authenticated-orcid":false,"given":"Hideki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Tokai National Higher Education and Research System , Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6067-6833","authenticated-orcid":false,"given":"Yuji","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Tokai National Higher Education and Research System , Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Tokai National Higher Education and Research System , Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9740-2142","authenticated-orcid":false,"given":"Masato","family":"Mutsuga","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Tokai National Higher Education and Research System , Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"2023111117031258600_ivad170-B1","first-page":"753","article-title":"The median sternal incision in intracardiac surgery with extracorporeal circulation; 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