{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:58:42Z","timestamp":1793383122073,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Intraoperative bacterial airway colonization seems to be associated with an increased risk of postoperative pneumonia (POP). It can be easily assessed by performing a bronchial aspirate (BA). The objective of this study is to assess the diagnostic performance of the BA to predict POP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We conducted a single-centre retrospective observational study over a period of 10\u2009years, from 1 January 2011 to 30 December 2020. The population study included patients admitted for a scheduled pulmonary resection surgery for lung cancer. Patients were classified into 2 populations depending on whether or not they developed a POP. Uni- and multivariable analyses were performed to identify risk factors for developing POP. The diagnostic performance of BA was represented by its sensitivity, specificity and positive and negative predictive values.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 1006 patients were included in the study. Uni- and multivariable analyses found that a positive BA was independently associated with a greater risk of developing POP with an odds ratio of 6.57 [4.165\u201310.865]; P\u2009&amp;lt;\u20090.001. Its specificity was 95%, sensitivity was 31%, positive predictive value was 66% and negative predictive value was 81%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>A positive intraoperative BA is an independent risk factor for POP after lung cancer surgery. Further trials are required to validate the systematic implementation of BA as an early diagnostic tool for POP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivad212","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T14:31:43Z","timestamp":1706884303000},"source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic value of systematic bronchial aspirate on postoperative pneumonia after pulmonary resection surgery for lung cancer: a monocentre retrospective study"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3482-0974","authenticated-orcid":false,"given":"Olivier","family":"Georges","sequence":"first","affiliation":[{"name":"Thoracic Surgery Department, Amiens University Hospital , Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-716X","authenticated-orcid":false,"given":"Osama","family":"Abou Arab","sequence":"additional","affiliation":[{"name":"Anesthesiology and Critical Care Department, Amiens University Hospital , Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Ben Rahal","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Amiens University Hospital , Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"de Dominicis","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Amiens University Hospital , Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro Witte","family":"Pfister","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Amiens University Hospital , Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoni","family":"Merlusca","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Amiens University Hospital , Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules","family":"Iquille","sequence":"additional","affiliation":[{"name":"Thoracic and Vascular Surgery Department, Saint-Brieux Hospital , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-4951","authenticated-orcid":false,"given":"Pascal","family":"Berna","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Clinique Victor Pauchet , Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"2024020806580297300_ivad212-B1","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.7314\/APJCP.2014.15.7.3071","article-title":"Risk factors of postoperative nosocomial pneumonia in stage I\u2013IIIa lung cancer patients","volume":"15","author":"Wang","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"2024020806580297300_ivad212-B2","first-page":"309","article-title":"Airways colonizations in patients undergoing lung cancer surgery","volume":"40","author":"D\u2019Journo","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"2024020806580297300_ivad212-B3","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/thx.2009.123083","article-title":"Postoperative pulmonary complications following thoracic surgery: are there any modifiable risk factors?","volume":"65","author":"Agostini","year":"2010","journal-title":"Thorax"},{"key":"2024020806580297300_ivad212-B4","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/JTO.0b013e3182862e7e","article-title":"Influence of postoperative infectious complications on long-term survival of lung cancer patients: a population-based cohort study","volume":"8","author":"Andalib","year":"2013","journal-title":"J Thorac Oncol"},{"key":"2024020806580297300_ivad212-B5","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1164\/rccm.200510-1556OC","article-title":"Postoperative pneumonia after major lung resection","volume":"173","author":"Schussler","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"2024020806580297300_ivad212-B6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-3-319-19908-5_14","article-title":"Pneumonia after thoracic surgery","author":"\u00d6zcan","year":"2017","journal-title":"Postop Care Thorac Surg"},{"key":"2024020806580297300_ivad212-B7","doi-asserted-by":"crossref","first-page":"e069382","DOI":"10.1136\/bmjopen-2022-069382","article-title":"Index hospital cost of adverse events following thoracic surgery: a systematic review of economic literature","volume":"13","author":"Jones","year":"2023","journal-title":"BMJ Open"},{"key":"2024020806580297300_ivad212-B8","first-page":"1200","article-title":"Airway bacterial colonization in patients with non-small cell lung cancer and the alterations during the perioperative period","volume":"6","author":"Mei","year":"2014","journal-title":"J Thorac Dis"},{"key":"2024020806580297300_ivad212-B9","first-page":"239","article-title":"Preoperatiove airway bacterial colonization: the missing link between non-small cell lung cancer following lobectomy and postoperative pneumonia?","volume":"20","author":"Gao","year":"2017","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"2024020806580297300_ivad212-B10","doi-asserted-by":"crossref","first-page":"101192","DOI":"10.1016\/j.accpm.2022.101192","article-title":"The French clinical research in the European Community regulation era","volume":"42","author":"Toulouse","year":"2023","journal-title":"Anaesth Crit Care Pain Med"},{"key":"2024020806580297300_ivad212-B11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"von Elm","year":"2008","journal-title":"J Clin Epidemiol"},{"key":"2024020806580297300_ivad212-B12","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.accpm.2019.02.017","article-title":"Antibioprophylaxis in surgery and interventional medicine (adult patients). Update 2017","volume":"38","author":"Martin","year":"2019","journal-title":"Anaesth Crit Care Pain Med"},{"key":"2024020806580297300_ivad212-B13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1183\/09031936.00184308","article-title":"ERS\/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)","volume":"34","author":"Brunelli","year":"2009","journal-title":"Eur Respir J"},{"key":"2024020806580297300_ivad212-B14","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-micro-091014-104209","article-title":"Mechanisms of bacterial colonization of the respiratory tract","volume":"69","author":"Siegel","year":"2015","journal-title":"Annu Rev Microbiol"},{"key":"2024020806580297300_ivad212-B15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13613-018-0444-0","article-title":"Brief summary of French guidelines for the prevention, diagnosis and treatment of hospital-acquired pneumonia in ICU","volume":"8","author":"Leone","year":"2018","journal-title":"Ann Intens Care"},{"key":"2024020806580297300_ivad212-B16","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.21037\/jtd.2017.04.42","article-title":"Identifying patients at higher risk of pneumonia after lung resection","volume":"9","author":"Liu","year":"2017","journal-title":"J Thorac Dis"},{"key":"2024020806580297300_ivad212-B17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jss.2022.11.021","article-title":"A clinical prediction model for postoperative pneumonia after lung cancer surgery","volume":"284","author":"Zhou","year":"2023","journal-title":"J Surg Res"},{"key":"2024020806580297300_ivad212-B18","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bja.2018.02.007","article-title":"A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications","volume":"120","author":"Abbott","year":"2018","journal-title":"Br J Anaesth"},{"key":"2024020806580297300_ivad212-B19","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/resp.13032","article-title":"The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD","volume":"22","author":"Leung","year":"2017","journal-title":"Respirology"},{"key":"2024020806580297300_ivad212-B20","first-page":"1230","article-title":"Risk factors for postoperative complications after lung resection for non-small cell lung cancer in elderly patients at a single institution in China","volume":"6","author":"Pei","year":"2014","journal-title":"J Thorac Dis"},{"key":"2024020806580297300_ivad212-B21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jinf.2023.01.037","article-title":"Diagnostic value of molecular tests for the management of postoperative pneumonia in thoracic surgery","volume":"86","author":"Turpin","year":"2023","journal-title":"J Infect"},{"key":"2024020806580297300_ivad212-B22","doi-asserted-by":"crossref","first-page":"777564","DOI":"10.3389\/fonc.2021.777564","article-title":"An external-validated algorithm to predict postoperative pneumonia among elderly patients with lung cancer after video-assisted thoracoscopic surgery","volume":"11","author":"Song","year":"2021","journal-title":"Front Oncol"},{"key":"2024020806580297300_ivad212-B23","doi-asserted-by":"crossref","first-page":"E233","DOI":"10.1503\/cjs.001919","article-title":"Enhanced recovery after video-assisted thoracoscopic surgery lobectomy: a prospective, historically controlled, propensity-matched clinical study","volume":"63","author":"Tahiri","year":"2020","journal-title":"Can J Surg"},{"key":"2024020806580297300_ivad212-B24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/0885066608327097","article-title":"The utility of the clinical pulmonary infection score","volume":"24","author":"Rosbolt","year":"2009","journal-title":"J Intensive Care Med"},{"key":"2024020806580297300_ivad212-B25","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.athoracsur.2007.05.059","article-title":"Postoperative pneumonia after major pulmonary resections: an unsolved problem in thoracic surgery","volume":"84","author":"Radu","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"2024020806580297300_ivad212-B26","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1128\/JCM.02918-14","article-title":"Correlation between sputum and bronchoalveolar lavage fluid cultures","volume":"53","author":"Dubourg","year":"2015","journal-title":"J Clin Microbiol"}],"container-title":["Interdisciplinary CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivad212\/56555985\/ivad212.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/38\/2\/ivad212\/56620441\/ivad212.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/38\/2\/ivad212\/56620441\/ivad212.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T06:58:22Z","timestamp":1707375502000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivad212\/7596639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,2]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivad212","relation":{},"ISSN":["2753-670X"],"issn-type":[{"value":"2753-670X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2,1]]},"published":{"date-parts":[[2024,2,1]]},"article-number":"ivad212"}}