{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:37Z","timestamp":1753877077458,"version":"3.41.2"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Grant-in-Aid for Scientific Research","award":["20K17747","22K08974"],"award-info":[{"award-number":["20K17747","22K08974"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Histidine-rich glycoprotein has been reported as an anti-inflammatory glycoprotein that inhibits acute lung injury in mice with sepsis and as a prognostic biomarker in patients with sepsis. We investigated the relationship between plasma concentrations of histidine-rich glycoprotein and the risk of occurrence of primary graft dysfunction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>According to the primary graft dysfunction grade at post-transplant 72\u2009h, patients who underwent lung transplantation were divided into three groups: non-primary graft dysfunction group (grade 0\u20131), moderate primary graft dysfunction group (grade 2), and severe primary graft dysfunction group (grade 3). The plasma concentrations of histidine-rich glycoprotein measured daily during the first post-transplant 7\u2009days were compared among the three groups. Appropriate cutoff values of the concentrations were set for survival analyses after lung transplantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 68 patients were included. The plasma histidine-rich glycoprotein concentration at post-transplant 72\u2009h was significantly lower in the severe primary graft dysfunction group (n\u2009=\u20097) than in the other two groups [non-primary graft dysfunction group (n\u2009=\u200943), P\u2009=\u20090.042; moderate primary graft dysfunction group (n\u2009=\u200918), P\u2009=\u20090.040]. Patients with plasma histidine-rich glycoprotein concentration \u226534.4\u2009\u00b5g\/ml at post-transplant 72\u2009h had significantly better chronic lung allograft dysfunction-free survival (P\u2009=\u20090.012) and overall survival (P\u2009=\u20090.037) than those with the concentration &amp;lt;34.4\u2009\u00b5g\/ml.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Plasma histidine-rich glycoprotein concentrations at post-transplant 72\u2009h might be associated with the risk of development of primary graft dysfunction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivae021","type":"journal-article","created":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T05:16:30Z","timestamp":1707023790000},"source":"Crossref","is-referenced-by-count":0,"title":["Plasma concentrations of histidine-rich glycoprotein in primary graft dysfunction after lung transplantation"],"prefix":"10.1093","volume":"38","author":[{"given":"Toshio","family":"Shiotani","sequence":"first","affiliation":[{"name":"Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital , Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6649-4777","authenticated-orcid":false,"given":"Seiichiro","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital , Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Tomioka","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital , Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital , Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Mitsuhashi","sequence":"additional","affiliation":[{"name":"Center for Innovative Clinical Medicine, Okayama University Hospital , Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2463-9696","authenticated-orcid":false,"given":"Ken","family":"Suzawa","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital , Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Shien","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital , Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaroh","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital , Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital , Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital , Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7588-6745","authenticated-orcid":false,"given":"Shinichi","family":"Toyooka","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital , Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,2,3]]},"reference":[{"key":"2024021622470175700_ivae021-B1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.healun.2021.07.021","article-title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-eighth adult lung transplantation report - 2021; 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