{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:26Z","timestamp":1753877066167,"version":"3.41.2"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>This study aimed to analyse the surgical outcomes for recurrent thymic epithelial tumours and identify the factors associated with post-recurrence survival, using an updated Japanese nationwide database.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The cohort that developed recurrence after the initial resection was extracted from an updated database of patients whose thymic epithelial tumours were treated surgically between 1991 and 2010. Furthermore, we reviewed clinicopathological and prognostic factors of re-resected cases. Post-recurrence survival outcomes and cause-specific deaths in non-re-resected cases were also reviewed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>We enrolled 191 patients who underwent re-resection and 259 patients who did not. In the surgery group, more patients with early stage disease, less aggressive World Health Organization (WHO) histological classification, initial complete resection and shorter recurrence-free intervals were included. Non-thymic carcinoma, absence of preoperative treatment, longer recurrent-free interval, single-site recurrence and R0-1 re-resection were all significantly favourable prognostic factors for post-recurrence survival in the surgery group, according to univariable analyses. Non-thymic carcinoma histology, longer recurrence-free interval and R0-1 re-resection were identified as independent prognostic factors according to multivariable analysis. The post-recurrence survival of the entire cohort with R2 re-resection was significantly better than that of the non-surgery group, although it was not demonstrated that patients with thymoma who underwent R2 re-resection had significantly better post-recurrence and lower cause-specific death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>R0-1 re-resection was newly identified as a prognostic factor after re-resection, in addition to non-thymic carcinoma histological classification and longer recurrence-free intervals, as documented in the initial report.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivae064","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T16:59:28Z","timestamp":1718729968000},"source":"Crossref","is-referenced-by-count":0,"title":["Updated outcomes of surgical treatment for recurrent thymic tumour: a report from the Japanese nationwide database"],"prefix":"10.1093","volume":"38","author":[{"given":"Tetsuya","family":"Mizuno","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Nagoya University Graduate School of Medicine , Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyofumi Fengshi","family":"Chen-Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Nagoya University Graduate School of Medicine , Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Chiba University Graduate School of Medicine , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meinoshin","family":"Okumura","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Osaka Toneyama Medical Center , Toyonaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokyo Medical University , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Second Department of Surgery, University of Occupational and Environmental Health , Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Maniwa","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Kobe University Graduate School of Medicine , Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Kanzaki","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Tokyo Women\u2019s Medical University , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kumamoto University Graduate School of Medical Sciences , Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Japanese Association for Research on the Thymus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"2024062213160297700_ivae064-B1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/JTO.0000000000000378","article-title":"Surgical management of recurrent thymic epithelial tumors: a retrospective analysis based on the Japanese nationwide database","volume":"10","author":"Mizuno","year":"2015","journal-title":"J Thorac 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