{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:05:33Z","timestamp":1792091133737,"version":"4.4.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Anomalous aortic origin of a coronary artery (AAOCA) is a group of rare congenital heart defects with various clinical presentations. The lifetime-risk of an individual living with AAOCA is unknown, and data from multicentre registries are urgently needed to adapt current recommendations and guide optimal patient management. The European AAOCA Registry (EURO-AAOCA) aims to assess differences with regard to AAOCA management between centres.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>EURO-AAOCA is a prospective, multicentre registry including 13 European centres. Herein, we evaluated differences in clinical presentations and management, treatment decisions and surgical outcomes across centres from January 2019 to June 2023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 262 AAOCA patients were included, with a median age of 33\u2009years (12\u201353) with a bimodal distribution. One hundred thirty-nine (53.1%) were symptomatic, whereas chest pain (n\u2009=\u200974, 53.2%) was the most common complaint, followed by syncope (n\u2009=\u200921, 15.1%). Seven (5%) patients presented with a myocardial infarction, 2 (1.4%) with aborted sudden cardiac death. Right-AAOCA was most frequent (150, 57.5%), followed by left-AAOCA in 51 (19.5%), and circumflex AAOCA in 20 (7.7%). There were significant differences regarding diagnostics between age groups and across centres. Seventy-four (28.2%) patients underwent surgery with no operative deaths; minor postoperative complications occurred in 10 (3.8%) cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Currently, no uniform agreement exists among European centres with regard to diagnostic protocols and clinical management for AAOCA variants. Although surgery is a safe procedure in AAOCA, future longitudinal outcome data will hopefully shed light on how to best decide towards optimal selection of patients undergoing revascularization versus conservative treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivae074","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T22:17:53Z","timestamp":1713824273000},"source":"Crossref","is-referenced-by-count":7,"title":["First report from the European registry for anomalous aortic origin of coronary artery (EURO-AAOCA)"],"prefix":"10.1093","volume":"38","author":[{"given":"Christoph","family":"Gr\u00e4ni","sequence":"first","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern , Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselm W","family":"Stark","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern 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Cardiac, Thoracic, Vascular Sciences and Public Health, Cardiology Clinic, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Crea","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sarris","sequence":"additional","affiliation":[{"name":"2nd Department of Pediatric and Congenital Cardiac Surgery, Mitera Children\u2019s Hospital, Athens Heart Surgery Institute , Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elephterios","family":"Protopapas","sequence":"additional","affiliation":[{"name":"2nd Department of Pediatric and Congenital Cardiac Surgery, Mitera Children\u2019s Hospital, Athens Heart Surgery Institute , Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Sirico","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, Department of Woman and Child\u2019s Health, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Di Salvo","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, Department of Woman and Child\u2019s Health, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Pegoraro","sequence":"additional","affiliation":[{"name":"UOC Medicina dello Sport, Ospedale Ca\u2019 Foncello , Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Sarto","sequence":"additional","affiliation":[{"name":"UOC Medicina dello Sport, Ospedale Ca\u2019 Foncello , Treviso, 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