{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:31:19Z","timestamp":1771011079804,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Netherlands Organization for Health Research and Development ZonMW","award":["842001002"],"award-info":[{"award-number":["842001002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Surgical aortic valve replacement through conventional sternotomy yields excellent results. Minimally invasive techniques are deemed equally safe and serve as a viable and less traumatic alternative. However, it is unclear how both surgical techniques affect patient-reported outcomes. The objective of this trial is to compare postoperative cardiac-related quality of life and postoperative pain after upper hemisternotomy and conventional surgical aortic valve replacement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In this single-centre, open-label, investigator-initiated randomized clinical trial, patients were randomized to upper hemisternotomy or conventional full median sternotomy. Patients unable to undergo randomization were monitored prospectively (registry group). Primary outcome was cardiac-specific quality of life, measured with the Kansas City Cardiomyopathy Questionnaire up to 1 year postoperatively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Patients undergoing upper hemisternotomy had a significantly higher physical limitation domain score across all postoperative time points than patients undergoing conventional surgical aortic valve replacement (estimated mean difference 2.12 points; P\u2009=\u20090.014). Patients undergoing upper hemisternotomy were more likely to have a pain score &amp;lt;30 the first 2 days postoperatively than patients undergoing conventional surgical aortic valve replacement (odds ratio 2.63; P\u2009=\u20090.007). This was associated with reduced opioid analgesic intake. Postoperative surgical outcome did not differ between both groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Surgical aortic valve replacement through both conventional sternotomy and upper hemisternotomy resulted in clinically similar and important improvements in quality of life, with a small advantage for upper hemisternotomy, while there was no compromise in safety.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivae083","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T05:12:42Z","timestamp":1715836362000},"source":"Crossref","is-referenced-by-count":1,"title":["Postoperative quality of life and pain after upper hemisternotomy and conventional median sternotomy for aortic valve replacement: results of a randomized clinical trial"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9100-9155","authenticated-orcid":false,"given":"Idserd D G","family":"Klop","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, St Antonius Hospital , Nieuwegein, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart P","family":"Van Putte","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St Antonius Hospital , Nieuwegein, Netherlands"},{"name":"Department of Cardiothoracic Surgery, AMC Heart Centre, Amsterdam University Medical Center , Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey T L","family":"Kloppenburg","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St Antonius Hospital , Nieuwegein, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J M","family":"Klautz","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, AMC Heart Centre, Amsterdam University Medical Center , Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3728-6933","authenticated-orcid":false,"given":"Mirjam A G","family":"Sprangers","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Amsterdam UMC Location University of Amsterdam , Amsterdam, Netherlands"},{"name":"Department of Mental Health, Amsterdam Public Health , Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pythia T","family":"Nieuwkerk","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Amsterdam UMC Location University of Amsterdam , Amsterdam, 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