{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:15:19Z","timestamp":1772165719262,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:00:00Z","timestamp":1714867200000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kuopio University Hospital Research Residue Funding","award":["KP11620"],"award-info":[{"award-number":["KP11620"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The objective of this study was primarily to compare four-dimensional flow magnetic resonance imaging metrics in the ascending aorta (AA) of patients with right\u2013left fusion type bicuspid aortic valve (RL-BAV) and repaired coarctation of the aorta (CoA) to RL-BAV without CoA. Metrics of patients with RL-BAV were also compared to the matched group of patients with common tricuspid aortic valve (TAV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Eleven patients with RL-BAV and CoA, 11 patients with RL-BAV without CoA and 22 controls with TAV were investigated. Peak velocity (cm\/s), peak flow (ml\/s) and flow displacement (%) were analysed at 5 pre-defined AA levels. In addition, regional wall shear stress (WSS, mN\/m2), circumferential WSS (WSSc) and axial WSS (WSSa) at all levels were quantified in 6 sectors of the aortic circle. Averaged WSS values on each level (WSSavg, WSSc, avg and WSSa, avg) were calculated as well.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Peak velocity at the proximal tubular AA was significantly lower in BAV and CoA group (P\u2009=\u20090.047) compared to BAV without CoA. In addition, the WSSa, avg was found to be higher for the BAV and CoA group at proximal AA respectively (P\u2009=\u20090.040). No other significant differences were found between these groups. BAV group\u2019s peak velocity was higher at every level (P\u2009&amp;lt;\u20090.001\u20130.004) compared to TAV group. Flow displacement was significantly higher for the BAV group at every level (P\u2009&amp;lt;\u20090.001) besides at the most distal level. All averaged WSS values were significantly higher in BAV patients in distal AA (P\u2009&amp;lt;\u20090.001\u20130.018).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Repaired CoA does not relevantly alter four-dimensional flow metrics in the AA of patients with RL-BAV. However, RL-BAV majorly alters flow dynamics in the AA when compared to patients with TAV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration number<\/jats:title>\n                  <jats:p>https:\/\/www.clinicaltrials.gov\/study\/NCT05065996, Unique Protocol ID 5063566<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivae086","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T20:21:52Z","timestamp":1714940512000},"source":"Crossref","is-referenced-by-count":2,"title":["Repaired coarctation of the aorta does not affect four-dimensional flow metrics in bicuspid aortic valve disease"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7997-7182","authenticated-orcid":false,"given":"Teemu","family":"Kiljander","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tampere University Hospital, Heart Hospital NOVA , Jyv\u00e4skyl\u00e4, Finland"},{"name":"Institute of Clinical Medicine, University of Eastern Finland , Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petteri","family":"Kauhanen","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Center, Kuopio University Hospital , Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saara","family":"Sillanm\u00e4ki","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Eastern Finland , Kuopio, Finland"},{"name":"Diagnostic Imaging Center, Kuopio University Hospital , Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Line","family":"Lottonen-Raikaslehto","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Center, Kuopio University Hospital , Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minna","family":"Husso","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Center, Kuopio University Hospital , Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Yl\u00e4-Herttuala","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Center, Kuopio University Hospital , Kuopio, Finland"},{"name":"A.I. 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