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Preoperative cerebrospinal fluid analysis was positive for anti-contactin-associated protein-like 2 antibody; possible paraneoplastic limbic encephalitis was diagnosed. Tumour resection was performed. Pathological examination showed thymic neuroendocrine tumour, stage IV. Postoperatively, the patient was treated with everolimus for adjuvant therapy, with complete improvement of encephalitis symptoms. The patient remained well without tumour recurrence or exacerbation of psychiatric disorders for 14\u2009months after the operation.<\/jats:p>","DOI":"10.1093\/icvts\/ivae103","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T04:52:06Z","timestamp":1715748726000},"source":"Crossref","is-referenced-by-count":2,"title":["Successful management of thymic neuroendocrine tumour with paraneoplastic limbic encephalitis"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3615-1962","authenticated-orcid":false,"given":"Kaoru","family":"Fukuyama","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Osaka General Medical Center , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunobu","family":"Funakoshi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Osaka General Medical Center , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"2024053100012432700_ivae103-B1","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1097\/JTO.0b013e31818e1092","article-title":"Paraneoplastic limbic encephalitis due to thymic carcinoid","volume":"3","author":"Davis","year":"2008","journal-title":"J Thorac Oncol"},{"key":"2024053100012432700_ivae103-B2","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1111\/j.1468-1331.2008.02328.x","article-title":"Paraneoplastic neurological syndromes in patients with carcinoid","volume":"15","author":"Tschernatsch","year":"2008","journal-title":"Eur J Neurol"},{"key":"2024053100012432700_ivae103-B3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1001\/jamaneurol.2022.4251","article-title":"Autoimmune encephalitis misdiagnosis in adults","volume":"80","author":"Flanagan","year":"2023","journal-title":"JAMA Neurol"},{"key":"2024053100012432700_ivae103-B4","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1097\/JTO.0000000000000300","article-title":"Paraneoplastic disorders in thymoma patients","volume":"9","author":"Evoli","year":"2014","journal-title":"J Thorac Oncol"},{"key":"2024053100012432700_ivae103-B5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.annonc.2021.01.003","article-title":"Lung and thymic carcinoids: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"32","author":"Baudin","year":"2021","journal-title":"Ann Oncol"}],"container-title":["Interdisciplinary CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivae103\/57708128\/ivae103.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/38\/5\/ivae103\/58012053\/ivae103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/38\/5\/ivae103\/58012053\/ivae103.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T01:04:02Z","timestamp":1717117442000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivae103\/7675476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivae103","relation":{},"ISSN":["2753-670X"],"issn-type":[{"value":"2753-670X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5,1]]},"published":{"date-parts":[[2024,5,1]]},"article-number":"ivae103"}}