{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:29:32Z","timestamp":1784939372631,"version":"3.55.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The goal of this study was to investigate the impact of onset-to-cut time on mortality in patients undergoing surgery for stable acute type A aortic dissection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Patients who underwent surgery for acute type A aortic dissection between January 2006 and December 2021 and available onset-to-cut times were included. Patients with unstable aortic dissection (preoperative shock, intubation, resuscitation, coma, pericardial tamponade and local\/systemic malperfusion syndromes) were excluded. After descriptive analysis, a multivariable binary logistic regression for 30-day mortality was performed. A receiver operating characteristic curve for onset-to-cut time and 30-day mortality was calculated. Restricted cubic splines were designed to investigate the association between onset-to-cut time and survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The final cohort comprised 362 patients. The median onset-to-cut time was 543 (376\u20131155) min. The 30-day mortality was 9%. Only previous myocardial infarction (P\u2009=\u20090.018) and prolonged cardiopulmonary bypass time (P\u2009&amp;lt;\u20090.001) were identified as independent risk factors for 30-day mortality. The corresponding area under the receiver operating characteristic curve showed a value of 0.49. Restricted cubic splines did not indicate an association between onset-to-cut time and survival (P\u2009=\u20090.316).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Onset-to-cut time in the setting of stable acute type A aortic dissection does not seem to be a valid predictor of 30-day mortality in patients undergoing surgery and stayed stable during the preoperative course.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivae130","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T08:03:00Z","timestamp":1720252980000},"source":"Crossref","is-referenced-by-count":1,"title":["The impact of onset-to-cut time in surgery for stable acute type A aortic dissection\u2014a single-centre retrospective cohort study"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0339-5791","authenticated-orcid":false,"given":"Leonard","family":"Pitts","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1 , Berlin 13353, Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1 , Berlin 10117, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kofler","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1 , Berlin 13353, Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1 , Berlin 10117, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Montagner","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1 , Berlin 13353, Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1 , Berlin 10117, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Heck","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1 , Berlin 13353, Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1 , Berlin 10117, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan Dominik","family":"Kurz","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1 , Berlin 13353, Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1 , Berlin 10117, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru Claudiu","family":"Paun","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1 , Berlin 13353, Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1 , Berlin 10117, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-8620","authenticated-orcid":false,"given":"Volkmar","family":"Falk","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1 , Berlin 13353, Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1 , Berlin 10117, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Berlin , Germany"},{"name":"Department of Health Sciences and Technology, Translational Cardiovascular Technologies, Institute of Translational Medicine, Swiss Federal Institute of Technology (ETH) \u2003 , Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-6375","authenticated-orcid":false,"given":"J\u00f6rg","family":"Kempfert","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1 , Berlin 13353, Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1 , Berlin 10117, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"2024082301580706700_ivae130-B1","first-page":"279","article-title":"State of the art review: surgical treatment of acute type A aortic 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