{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:37:33Z","timestamp":1780627053839,"version":"3.54.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>In some centrally located lung cancers, complete excision of the mass cannot be achieved with parenchymal-sparing procedures and pneumonectomy may be required. The mortality and morbidity rates of pneumonectomy were reported to be considerably high. Here, we investigated the effectivity of modified frailty index-5 (MFI-5) in patients undergoing pneumonectomy for non-small cell lung cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Data of patients who underwent pneumonectomy for non-small cell lung cancer between January 2018 and December 2023 were reviewed retrospectively. The MFI-5 score was determined by preoperative diabetes mellitus, hypertension, chronic obstructive pulmonary diseases, congestive heart failure and functional status. The effectiveness of the MFI-5 score for the presence of postoperative major complications and 30-day mortality was investigated by multivariate logistic regression analysis. A P-value &amp;lt;0.05 was considered statistically significant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 107 patients who met the inclusion criteria were included in the study. Eight (7.5%) of patients were female, and the mean age was 61.4\u2009\u00b1\u20098.7. The MFI-5 score was 0 in 48 patients (44.9%), 1 in 27 patients (25.2%) and 2 in 20 patients (18.7%). Postoperative 30-day mortality was detected in 4 patients (3.7%), and the major complications occurred in 42 patients (39.3%). In multivariate analysis, an MFI-5 score of 2 or higher (P\u2009=\u20090.008, OR: 4.9) was statistically significant for complications, whereas age, gender, side of the operation, &amp;lt;2 MFI-5 score, tumor diameter, type of surgery and lymph node metastasis status were not statistically significant (P\u2009&amp;gt;\u20090.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The MFI-5 score is a significant indicator for predicting major postoperative events in patients who underwent pneumonectomy for non-small cell lung cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical registration number<\/jats:title>\n                  <jats:p>2024-323, approved by Gazi University Local Ethics Committee.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivae179","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T19:16:58Z","timestamp":1730315818000},"source":"Crossref","is-referenced-by-count":2,"title":["The prognostic significance of modified frailty index-5 in patients undergoing pneumonectomy for lung cancer"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5402-9031","authenticated-orcid":false,"given":"Muhammet","family":"Sayan","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Gazi University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4696-1781","authenticated-orcid":false,"given":"Bengisu","family":"Artiran","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Gazi University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8026-3807","authenticated-orcid":false,"given":"Funda","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Gazi University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8589-8215","authenticated-orcid":false,"given":"Mahir","family":"Fattahov","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Gazi University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-9770","authenticated-orcid":false,"given":"Irmak","family":"Akarsu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Gazi University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4123-1131","authenticated-orcid":false,"given":"Muhammet Tarik","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Gazi University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5565-7021","authenticated-orcid":false,"given":"Gunel","family":"Ahmadova","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Gazi University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-8128","authenticated-orcid":false,"given":"Aysegul","family":"Kurtoglu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Gazi University , 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