{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:26:07Z","timestamp":1793179567739,"version":"4.5.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CORCYM S.r.l."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Memo 4D is a semi-rigid ring with an exclusive saddle shape and progressive increased anteroposterior diameter. This preliminary analysis reports 30-day clinical and haemodynamic outcomes of the MANTRA Memo 4D sub-study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>MANTRA is an \u2018umbrella\u2019 prospective, multicentre, worldwide post-market study to collect real-life safety and performance data on the Corcym devices. Clinical and echocardiographic outcomes were gathered preoperatively, at discharge and each follow-up. KCCQ-12 questionnaires were collected preoperatively and at 30 days. Echocardiographic studies were performed per a predefined protocol and assessed by an independent core laboratory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In total, 166 patients (52, 31.3% female, mean age 60.7\u2009\u00b1\u200911.4\u2009years) underwent mitral valve repair with Memo 4D in 17 international institutions between July 2021 and June 2023 (enrolment is still ongoing). Primary was the most common aetiology (157, 94.6%), of which 33 cases of Barlow\u2019s disease (19.9%); secondary mitral regurgitation was present in six cases (3.6%). Thirty-day mortality was 0.6% (1). One stroke event (0.6%), one acute kidney failure (0.6%), one myocardial infarction (0.6%) and two reoperations within 30\u2009days were reported. Surgery marked improvement in the patient\u2019s NYHA class associated with a significant increase in KCCQ-12 summary score, from 69.1 (SD = 23.7) preoperatively to 83.9 (SD = 15.7) at 30\u2009days. End-diastolic left ventricular diameters decreased from 55.19 (SD = 7.10) preoperatively to 52.70 (SD = 3.76) mm at 30\u2009days, and left atrial volume decreased from 125.79 (SD = 46.33) preoperatively to 91.51 (SD = 37.20) ml at 30\u2009days. Mitral regurgitation significantly reduced after the operation and up to 30-day follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Mitral valve repair with Memo 4D is associated with good clinical and haemodynamic outcomes in the early period.<\/jats:p>\n                  <jats:p>MANTRA ClinicalTrials.gov number NCT05002543.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivae208","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T21:20:38Z","timestamp":1734038438000},"source":"Crossref","is-referenced-by-count":2,"title":["Mitral valve repair with the semi-rigid Memo 4D annuloplasty ring: early clinical and echocardiographic outcomes from the MANTRA study"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7910-5152","authenticated-orcid":false,"given":"Omer","family":"Dzemali","sequence":"first","affiliation":[{"name":"Clinic for Cardiac Surgery, University Hospital of Zurich , Zurich,","place":["Switzerland"]},{"name":"Clinic for Cardiac Surgery, City Hospital of Zurich\u2014Triemli , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Rodriguez Cetina Biefer","sequence":"additional","affiliation":[{"name":"Clinic for Cardiac Surgery, University Hospital of Zurich , Zurich,","place":["Switzerland"]},{"name":"Clinic for Cardiac Surgery, City Hospital of Zurich\u2014Triemli , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Di Eusanio","sequence":"additional","affiliation":[{"name":"Department for Cardiac Surgery, Ospedali Riuniti Ancona , Ancona,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Fabre","sequence":"additional","affiliation":[{"name":"Department for Cardiac Surgery, Lens Hospital and Bois Bernard Private Hospital , Lens,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Troise","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Poliambulanza Foundation Hospital , Brescia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Bonaros","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Innsbruck Medical University , Innsbruck,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, IRCCS Policlinico San Donato , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong-Hoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Kerckhoff Klinik , Bad Nauheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Santarpino","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Citt\u00e0 di Lecce Hospital , Lecce,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Baeza","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospitals Cleveland Medical Center , Cleveland, OH,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pollari","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Surgery, Klinikum N\u00fcrnberg-Paracelsus Medical University , Nuremberg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Marcheix","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, CHU Toulouse Rangueil University Hospital , Toulouse,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Pacini","sequence":"additional","affiliation":[{"name":"Unit of Cardiac Surgery, Policlinico S.Orsola-Malpighi , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Argano","sequence":"additional","affiliation":[{"name":"The Cardiac Care Group, Policlinico Paolo Giaccone , Palermo,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Baghai","sequence":"additional","affiliation":[{"name":"Cardiac Surgery, King\u2019s College Hospital , 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Ospedaliero-Universitaria \u201cOspedali Riuniti\u201d di Trieste , Trieste,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Badano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istituto Auxologico Italiano, IRCCS , Milano,","place":["Italy"]},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Kempfert","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Herz-, Thorax- und Gef\u00e4\u00dfchirurgie Deutsches Herzzentrum der Charit\u00e9 , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"2025010521073615400_ivae208-B1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS guidelines for 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