{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T20:07:35Z","timestamp":1768594055590,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The common surgical treatment in patients with obstructive hypertrophic cardiomyopathy is septal myectomy. This involves resection of a segment of the myocardial septum and can be performed with and without concomitant anterior mitral valve leaflet extension (AMVLE). While both approaches have satisfying clinical outcomes, there is a lack of data regarding the added value of concomitant AMVLE. In particular, their impact on postoperative haemodynamics remains unexplored. Therefore, we conducted a study to assess the feasibility of utilizing four-dimensional-flow cardiac magnetic resonance imaging (4D-flow cardiac magnetic resonance imaging (CMR)) to investigate postoperative haemodynamic differences among both surgical approaches.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In this feasibility study, nine subjects underwent 4D-flow CMR evaluation, including three patients who underwent isolated myectomy, three patients with myectomy + AMVLE and three healthy controls. Primary end-points were aortic wall shear stress, left ventricular outflow tract (LVOT) peak velocity and peak kinetic energy in the LVOT and ascending aorta.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Results showed that patients who underwent myectomy with concomitant AMVLE exhibited (i) lower aortic wall shear stress (\u221221.2%), (ii) lower LVOT peak velocity (\u22126.3%), (iii) higher kinetic energy in the LVOT (+10.8%) and (iv) lower kinetic energy in the ascending aorta (\u221228.8%) compared to patients who underwent isolated myectomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Patients undergoing additional AMVLE exhibited a better trend towards the haemodynamic reference values from healthy controls compared to patients undergoing isolated myectomy. Our findings underscore the feasibility of 4D-flow CMR to assess postoperative haemodynamic differences in hypertrophic cardiomyopathy patients undergoing different surgical approaches. This highlights the potential of 4D-flow CMR to compare surgical strategies based on postoperative haemodynamics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical registration number<\/jats:title>\n                  <jats:p>Dutch National Medical Ethics Committee, registration number 2022.0078<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivae210","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T21:47:43Z","timestamp":1734385663000},"source":"Crossref","is-referenced-by-count":1,"title":["Feasibility of 4D-flow CMR for haemodynamic characterization in hypertrophic cardiomyopathy after septal myectomy with and without anterior mitral valve leaflet extension"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-991X","authenticated-orcid":false,"given":"Sulayman","family":"el Mathari","sequence":"first","affiliation":[{"name":"Department of 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