{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T12:50:32Z","timestamp":1786884632827,"version":"build-2736575974"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Aortic valve reconstruction with autologous glutaraldehyde-fixed pericardium (Ozaki procedure) represents an alternative to conventional prosthetic valve replacement, allowing excellent haemodynamic outcomes. We report two cases of subclinical leaflet thrombosis (SLT) at 12 and 23\u2009months of follow-up. Anticoagulation was initiated, and later echocardiography showed haemodynamic and mobility improvement. SLT is well documented for bioprosthetic valve. To our knowledge, this is the first report for Ozaki procedure in an adult population. Glutaraldehyde is known for cytotoxicity, and partial endothelialization can be responsible for thrombosis, creating favourable conditions for later endocarditis and degeneration. Anticoagulation should be recommended postoperatively for the first 3 months with control at 6 months. Finally, alternative treatment to glutaraldehyde should be investigated.<\/jats:p>","DOI":"10.1093\/icvts\/ivaf051","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T22:58:46Z","timestamp":1741129126000},"source":"Crossref","is-referenced-by-count":2,"title":["Subclinical leaflet thrombosis in Ozaki procedure"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6329-2280","authenticated-orcid":false,"given":"Mathieu","family":"van Steenberghe","sequence":"first","affiliation":[{"name":"Cardiovascular Surgery Unit, Cecil Clinic , Lausanne,","place":["Switzerland"]},{"name":"Cardiovascular Surgery Unit, H\u00f4pitaux Universitaires de Gen\u00e8ve , Geneva,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Perret","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Cecil Clinic , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick O","family":"Myers","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Unit, La Tour Hospital , Geneva,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Khatchatourov","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Unit, Cecil Clinic , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,1]]},"reference":[{"key":"2025031720171403400_ivaf051-B1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.athoracsur.2023.12.010","article-title":"Midterm outcomes after aortic valve neocuspidization (Ozaki procedure) in adults","volume":"117","author":"Ogami","year":"2024","journal-title":"Ann Thorac Surg"},{"key":"2025031720171403400_ivaf051-B2","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1056\/NEJMoa1509233","article-title":"Possible subclinical leaflet thrombosis in bioprosthetic aortic valves","volume":"373","author":"Makkar","year":"2015","journal-title":"N Engl J Med"},{"key":"2025031720171403400_ivaf051-B3","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/S0140-6736(17)30757-2","article-title":"Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study","volume":"389","author":"Chakravarty","year":"2017","journal-title":"Lancet"},{"key":"2025031720171403400_ivaf051-B4","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1016\/j.jacc.2016.09.958","article-title":"Prosthetic heart valve thrombosis","volume":"68","author":"Dangas","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2025031720171403400_ivaf051-B5","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.3390\/jcm12175740","article-title":"Early biological valve failure: structural valve degeneration, thrombosis, or endocarditis?","volume":"12","author":"Fazzari","year":"2023","journal-title":"J Clin Med"}],"container-title":["Interdisciplinary CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivaf051\/62210168\/ivaf051.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/40\/3\/ivaf051\/62210168\/ivaf051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/40\/3\/ivaf051\/62210168\/ivaf051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T20:17:35Z","timestamp":1742242655000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivaf051\/8046662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,5]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivaf051","relation":{},"ISSN":["2753-670X"],"issn-type":[{"value":"2753-670X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3]]},"published":{"date-parts":[[2025,3,1]]},"article-number":"ivaf051"}}