{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:13:26Z","timestamp":1783016006271,"version":"3.54.6"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Interest in Del Nido solution is increasing in adult cardiac surgery. This study compared Del Nido with Buckberg cardioplegia in patients undergoing isolated aortic valve replacement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A prospective, two-centre, randomized trial was conducted from July 2019 to August 2023, with adult patients undergoing first-time isolated aortic valve replacement, and were randomized to receive Buckberg (n\u2009=\u2009159) or Del Nido (n\u2009=\u2009152) solution. Primary end-point was Creatine Kinase and ultrasensitive Troponin T postoperative peak level.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 311 patients were recruited. Total cardioplegia volume was higher in Del Nido group (1000\u2009ml vs 374.5\u2009ml, P\u2009&amp;lt;\u20090.001). No differences were observed in peak Creatine Kinase or Troponin T levels (422 vs 407 U\/L and 282 vs 258\u2009ng\/L for Buckberg and Del Nido, respectively) or during postoperative days 1\u20135. After cross-clamp removal, patients in Del Nido group showed higher rates of spontaneous rhythm (66.7% vs 43.1%, P\u2009&amp;lt;\u20090.001) and less ventricular fibrillation requiring defibrillation (23.6% vs 49.7%, P\u2009&amp;lt;\u20090.001). Peak intraoperative glucose levels (128\u2009mg\/dl vs 198\u2009mg\/dl, P\u2009&amp;lt;\u20090.001) and insulin administration (18.1% vs 51.0%, P\u2009&amp;lt;\u20090.001) were lower in the Del Nido group. No other differences were found.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>No differences between Del Nido and Buckberg solutions were detected. Del Nido presents better intraoperative glycaemic control, higher spontaneous rhythm, less ventricular fibrillation requiring defibrillation after cross-clamp removal, and more comfortable surgical workflow due to less re-dose interruptions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CLINICAL REGISTRATION NUMBER<\/jats:title>\n                  <jats:p>EU-CTR number: 2018-002701-59.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivaf054","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T05:13:52Z","timestamp":1741670032000},"source":"Crossref","is-referenced-by-count":3,"title":["Buckberg versus Del Nido in isolated aortic valve replacement: a prospective, two-centre, randomized trial"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5864-519X","authenticated-orcid":false,"given":"Manel","family":"Tauron-Ferrer","sequence":"first","affiliation":[{"name":"Cardiac Surgery Department, Hospital de la Santa Creu i Sant Pau (HSCSP), IIB Sant Pau, Universitat Aut\u00f3noma de Barcelona , Barcelona,","place":["Spain"]},{"name":"CIBER-CV, ISCIII , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-3246","authenticated-orcid":false,"given":"Elena","family":"Rosell\u00f3-D\u00edez","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital de la Santa Creu i Sant Pau (HSCSP), IIB Sant Pau, Universitat Aut\u00f3noma de Barcelona , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0272-1704","authenticated-orcid":false,"given":"Christian","family":"Mu\u00f1oz-Guijosa","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital Universitario 12 de Octubre, Instituto de investigaci\u00f3n i+12, Universidad Complutense de Madrid , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Fern\u00e1ndez-DeVinzenzi","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital de la Santa Creu i Sant Pau (HSCSP), IIB Sant Pau, Universitat Aut\u00f3noma de Barcelona , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Montiel","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital de la Santa Creu i Sant Pau (HSCSP), IIB Sant Pau, Universitat Aut\u00f3noma de Barcelona , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Casellas","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital de la Santa Creu i Sant Pau (HSCSP), IIB Sant Pau, Universitat Aut\u00f3noma de Barcelona , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Irabien-Ortiz","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital de la Santa Creu i Sant Pau (HSCSP), IIB Sant Pau, Universitat Aut\u00f3noma de Barcelona , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Corominas-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital de la Santa Creu i Sant Pau (HSCSP), IIB Sant Pau, Universitat Aut\u00f3noma de Barcelona , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Piedra","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital de la Santa Creu i Sant Pau (HSCSP), IIB Sant Pau, Universitat Aut\u00f3noma de Barcelona , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignasi","family":"Juli\u00e0","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital Germans Trias i Pujol , Badalona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital Germans Trias i Pujol , Badalona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Cegarra","sequence":"additional","affiliation":[{"name":"Anesthesiology Department, Hospital de la Santa Creu i Sant Pau (HSCSP) , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Guadalupe","sequence":"additional","affiliation":[{"name":"Anesthesiology Department, Hospital de la Santa Creu i Sant Pau (HSCSP) , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Molina","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital de la Santa Creu i Sant Pau (HSCSP), IIB Sant Pau, Universitat Aut\u00f3noma de Barcelona , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F","family":"Tabilo","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital de la Santa Creu i Sant Pau (HSCSP), IIB Sant Pau, Universitat Aut\u00f3noma de Barcelona , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Gotsens-Asenjo","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital de la Santa Creu i Sant Pau (HSCSP), IIB Sant Pau, Universitat Aut\u00f3noma de Barcelona , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sobre","sequence":"additional","affiliation":[{"name":"Division of Perfusion, Hospital de la Santa Creu i Sant Pau (HSCSP) , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Gomez","sequence":"additional","affiliation":[{"name":"Division of Perfusion, Hospital de la Santa Creu i Sant Pau (HSCSP) , 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