{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:52:48Z","timestamp":1753876368503,"version":"3.41.2"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Our study aimed to evaluate factors influencing perioperative and long-term outcomes of patients undergoing curative-intent chest wall resection and reconstruction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A retrospective single-centre analysis was conducted on all patients undergoing curative-intent chest wall resection and reconstruction from 2010 to 2023. Perioperative outcome was analysed for the entire cohort. Overall survival and disease-free survival were analysed using the Kaplan\u2013Meier method and log-rank test and multivariable Cox proportional hazards regression models with a particular focus on patients with lung cancer and chest wall involvement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 143 consecutive patients (median age 62\u2009years, 44.1% females) were included, and 75% of patients received perioperative systemic therapy or radiation. Rib resection alone was performed in 69.9%, additional sternal resection in 16.1%, spine resection in 11.9% and clavicle resection in 2.1%. Additional resections included the lung (n\u2009=\u200975), diaphragm (n\u2009=\u20096), pericardium (n\u2009=\u20092), subclavian vein (n\u2009=\u20092), pulmonary artery (n\u2009=\u20091) and multiple structures (n\u2009=\u200922). Reconstruction was performed using synthetic protheses (n\u2009=\u200989), metallic (n\u2009=\u20096) or combinations of materials (n\u2009=\u200932). Median tumour diameter was 10\u2009cm; 88% were malignant. Local recurrence rate was 9.5%. Median disease-free survival (86 events) was 36\u2009months, and median overall survival (62 events) was 80\u2009months. The 5-year disease-free survival and overall survival were 54.1% and 74.1%, respectively. In patients with lung cancer, overall survival was significantly affected by age (P\u2009=\u20090.028), histology (P\u2009&amp;lt;\u20090.001), resection size &amp;gt;10\u2009cm (P\u2009=\u20090.018), postoperative performance status (P\u2009&amp;lt;\u20090.001) and postoperative complications (P\u2009&amp;lt;\u20090.001) in multivariable analysis and disease-free survival by postoperative performance status (P\u2009&amp;lt;\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Postoperative performance status is correlated with overall survival after chest wall resection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivaf126","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T04:38:46Z","timestamp":1748579926000},"source":"Crossref","is-referenced-by-count":0,"title":["Long-term outcome and prognostic factors after chest wall resection and reconstruction"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6426-5460","authenticated-orcid":false,"given":"Alba M","family":"Fernandez Gonzalez","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Medical University of Vienna , Vienna,","place":["Austria"]},{"name":"Department of Thoracic Surgery, University Hospital Puerta Del Mar , C\u00e1diz,","place":["Spain"]},{"name":"Comprehensive Center for Chest Diseases, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose R","family":"Matilla","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical University of Vienna , Vienna,","place":["Austria"]},{"name":"Comprehensive Center for Chest Diseases, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orsolya Anna","family":"Pipek","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Chest Diseases, Medical University of Vienna , Vienna,","place":["Austria"]},{"name":"Department of Physics of Complex Systems, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University , Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Gonzalez","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Chest Diseases, Medical University of Vienna , Vienna,","place":["Austria"]},{"name":"Department of Thoracic Surgery, University Hospital Cruces , Bilbao,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merjem","family":"Begic","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical University of Vienna , Vienna,","place":["Austria"]},{"name":"Comprehensive Center for Chest Diseases, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Megyesfalvi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical University of Vienna , Vienna,","place":["Austria"]},{"name":"Department of Thoracic Surgery, Semmelweis University and National Institute of Oncology , Budapest,","place":["Hungary"]},{"name":"Department of Pulmonology, National Koranyi Institute of Pulmonology , Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balazs","family":"D\u00f6me","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical University of Vienna , Vienna,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7787-991X","authenticated-orcid":false,"given":"Clemens","family":"Aigner","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical 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