{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T03:42:29Z","timestamp":1787283749403,"version":"build-2736575974"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutschen Herzzentrums M\u00fcnchen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Acute kidney injury commonly complicates congenital heart surgery with cardiopulmonary bypass, increasing morbidity and mortality. This study aimed to evaluate risk factors for postoperative acute kidney injury and its impact on outcomes after the Norwood procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Neonates undergoing the Norwood procedure from 2001 to 2022 were reviewed. Using modified neonatal Kidney Disease Improving Global Outcomes criteria, we assessed acute kidney injury and analysed its risk factors and impact on survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among the 355 patients who were included, severe acute kidney injury occurred in 100 (28.2%). Risk factors were low weight at Norwood &amp;lt;2.5\u2009kg (odds ratio: 3.0, P\u2009=\u20090.015) and extracorporeal membrane oxygenation support (odds ratio: 2.2, P\u2009=\u20090.013). Shunt type was not identified as a risk (P\u2009=\u20090.317). Acute kidney injury was an independent risk factor for in-hospital death (odds ratio 2.3, P\u2009=\u20090.010) but did not influence survival after hospital discharge (hazard ratio: 1.5, P\u2009=\u20090.230). The hazard ratio for mortality in patients with acute kidney injury compared to patients without acute kidney injury was 2.5, P\u2009&amp;lt;\u20090.001 with a modified Blalock\u2013Taussig\u2013Thomas shunt and 1.9, P\u2009=\u20090.010 with a right ventricle-to-pulmonary artery conduit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Severe acute kidney injury occurred in approximately a quarter of patients after the Norwood procedure and is an independent risk for in-hospital mortality, both in patients with a modified Blalock\u2013Taussig\u2013Thomas shunt and right ventricle-to-pulmonary artery conduit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivaf132","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T07:35:09Z","timestamp":1748763309000},"source":"Crossref","is-referenced-by-count":2,"title":["Cardiac surgery-associated acute kidney injury in neonatal Norwood procedure: incidence, risk factors and impact on mortality and outcomes"],"prefix":"10.1093","volume":"40","author":[{"given":"Laetitia","family":"Eberle","sequence":"first","affiliation":[{"name":"Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Division of Congenital and Pediatric Heart Surgery, University Hospital of Munich, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Europ\u00e4isches Kinderherzzentrum M\u00fcnchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-2724","authenticated-orcid":false,"given":"Muneaki","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Division of Congenital and Pediatric Heart Surgery, University Hospital of Munich, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Europ\u00e4isches Kinderherzzentrum M\u00fcnchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Palm","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6842-2988","authenticated-orcid":false,"given":"Thibault","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Division of Congenital and Pediatric Heart Surgery, University Hospital of Munich, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Europ\u00e4isches Kinderherzzentrum M\u00fcnchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Osawa","sequence":"additional","affiliation":[{"name":"Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Division of Congenital and Pediatric Heart Surgery, University Hospital of Munich, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Europ\u00e4isches Kinderherzzentrum M\u00fcnchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Niedermaier","sequence":"additional","affiliation":[{"name":"Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Division of Congenital and Pediatric Heart Surgery, University Hospital of Munich, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Europ\u00e4isches Kinderherzzentrum M\u00fcnchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Philipp","family":"Heinisch","sequence":"additional","affiliation":[{"name":"Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Division of Congenital and Pediatric Heart Surgery, University Hospital of Munich, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Europ\u00e4isches Kinderherzzentrum M\u00fcnchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Piber","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Balling","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2481-2017","authenticated-orcid":false,"given":"Alfred","family":"Hager","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ewert","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"H\u00f6rer","sequence":"additional","affiliation":[{"name":"Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Division of Congenital and Pediatric Heart Surgery, University Hospital of Munich, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , Munich,","place":["Germany"]},{"name":"Europ\u00e4isches Kinderherzzentrum M\u00fcnchen , 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