{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T19:00:06Z","timestamp":1778266806702,"version":"3.51.4"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>INSPIRIS RESILIA, launched in 2017, is a bioprosthetic aortic valve developed to improve durability and facilitate future valve-in-valve procedures. Despite its advanced design, many surgeons continue to use the PERIMOUNT MAGNA EASE valve, which has long-standing clinical validation. This study aimed to compare mid-term clinical and echocardiographic outcomes in patients under 70 undergoing aortic valve replacement with either prosthesis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective study of patients who underwent surgical aortic valve replacement between January 2018 and May 2023 at the University Hospital of Reims. The primary outcome was all-cause mortality at 1 year following surgical aortic valve replacement. Secondary outcomes included haemodynamic parameters, left ventricular ejection fraction, and major postoperative complications such as reintervention, stroke, pacemaker implantation, mediastinitis, transfusion, and new-onset atrial fibrillation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 300 patients were included: 52 received the INSPIRIS RESILIA valve and 248 received the PERIMOUNT MAGNA EASE valve. After matching, 52 patients from each group were compared. All-cause mortality at 3 years was 0% in the INSPIRIS group and 1.9% in the PERIMOUNT group. Mean transvalvular gradients were similar at 1 year (11.3 vs 11.2 mmHg) and 3 years (12.9 mmHg for both). Two cases of endocarditis-related reoperation occurred in the INSPIRIS group. No structural valve degeneration requiring surgery was observed. Postoperative aortic regurgitation was trivial or absent. Transfusion rates were lower in the INSPIRIS group (46.1% vs 69.2%, P\u2009=\u2009.017).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>INSPIRIS RESILIA and MAGNA EASE valves offer similar mid-term safety and performance in patients under 70 years of age.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivaf169","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T18:02:22Z","timestamp":1753466542000},"source":"Crossref","is-referenced-by-count":1,"title":["Mid-Term Outcomes After Aortic Valve Replacement in Patients Under 70: A Comparative Study of INSPIRIS RESILIA Versus PERIMOUNT MAGNA EASE Bioprostheses"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-8332","authenticated-orcid":false,"given":"Gabriel","family":"Saiydoun","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Piti\u00e9-Salpetri\u00e8re University Hospital, Sorbonne University , 75013 Paris,","place":["France"]},{"name":"Department of Cardiac Surgery, Henri Mondor University Hospital , 94000 Creteil,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elie","family":"Nassar","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Reims University Hospital , 51100 Reims,","place":["France"]},{"name":"Universit\u00e9 de Reims Champagne Ardenne , 51100 Reims,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad\u00e9","family":"Saad\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Strasbourg University Hospital , 67000 Strasbourg,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9825-3852","authenticated-orcid":false,"given":"Chadi","family":"Aludaat","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Rouen University Hospital , 76031 Rouen,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Reims University Hospital , 51100 Reims,","place":["France"]},{"name":"Universit\u00e9 de Reims Champagne Ardenne , 51100 Reims,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Alqdeimat","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Reims University Hospital , 51100 Reims,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito Giovanni","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Reims University Hospital , 51100 Reims,","place":["France"]},{"name":"Universit\u00e9 de Reims Champagne Ardenne , 51100 Reims,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"2025081218214755700_ivaf169-B1","doi-asserted-by":"crossref","first-page":"e018506","DOI":"10.1161\/JAHA.120.018506","article-title":"Degeneration of bioprosthetic heart valves: update 2020","volume":"9","author":"Kostyunin","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2025081218214755700_ivaf169-B2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.athoracsur.2023.11.036","article-title":"Five-year outcomes after bicuspid aortic valve replacement with a novel tissue bioprosthesis","volume":"118","author":"Bavaria","year":"2024","journal-title":"Ann Thorac Surg"},{"key":"2025081218214755700_ivaf169-B3","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.athoracsur.2021.12.058","article-title":"Five-year outcomes of the COMMENCE trial investigating aortic valve replacement with RESILIA tissue","volume":"115","author":"Bavaria","year":"2023","journal-title":"Ann Thorac Surg"},{"key":"2025081218214755700_ivaf169-B4","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/ejcts\/ezaa311","article-title":"Final 5-year outcomes following aortic valve replacement with a RESILIA tissue bioprosthesis","volume":"59","author":"Bartus","year":"2021","journal-title":"Eur J Cardiothorac Surg"},{"key":"2025081218214755700_ivaf169-B5","doi-asserted-by":"crossref","first-page":"ezae045","DOI":"10.1093\/ejcts\/ezae045","article-title":"Early and mid-term outcomes after aortic valve replacement using a novel tissue bioprosthesis: a systematic review","volume":"65","author":"Sef","year":"2024","journal-title":"Eur J Cardiothorac Surg"},{"key":"2025081218214755700_ivaf169-B6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ejcts\/ezab389","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"60","author":"Vahanian","year":"2021","journal-title":"Eur J Cardiothorac Surg"},{"key":"2025081218214755700_ivaf169-B7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/icvts\/ivab016","article-title":"Magna ease bioprosthetic aortic valve: mid-term haemodynamic outcomes in 1126 patients","volume":"32","author":"Thorp","year":"2021","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2025081218214755700_ivaf169-B8","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/ejcts\/ezab552","article-title":"Carpentier-Edwards Magna Ease bioprosthesis: a multicentre clinical experience and 12-year durability","volume":"61","author":"Piperata","year":"2022","journal-title":"Eur J Cardiothorac Surg"},{"key":"2025081218214755700_ivaf169-B9","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/jocs.14250","article-title":"Mitroflow and Perimount Magna 10-year outcomes: a direct propensity match analysis to assess reintervention rates and long follow-up mortality","volume":"34","author":"Theologou","year":"2019","journal-title":"J Card Surg"},{"issue":"3","key":"2025081218214755700_ivaf169-B10","doi-asserted-by":"crossref","first-page":"e220962","DOI":"10.1001\/jamanetworkopen.2022.0962","article-title":"Comparison of long-term performance of bioprosthetic aortic valves in Sweden from 2003 to 2018","volume":"5","author":"Persson","year":"2022","journal-title":"JAMA Netw Open"},{"key":"2025081218214755700_ivaf169-B11","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.athoracsur.2019.12.071","article-title":"Trifecta versus Perimount Magna Ease aortic valve 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