{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T09:10:05Z","timestamp":1755853805927,"version":"3.44.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Hospital of Reims"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Repairing severe mitral regurgitation (MR) in patients with degenerative bileaflet prolapse and reduced left ventricular ejection fraction (LVrEF) is challenging. The Free Margin Running Suture (FMRS) technique offers a non-resectional approach, but mid-term data are limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analysed 28 patients with bileaflet degenerative MR and LVrEF (\u226440%) undergoing FMRS. Primary outcomes were mid-term survival and MR recurrence; secondary outcomes included LVEF, in-hospital complications, transmitral gradient, coaptation length, and mitral valve orifice area.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean age was 59.3\u2009\u00b1\u200912.8 years; 69.4% were male. No perioperative deaths; 1 patient required ECMO. Mean aortic cross-clamp time was 47\u2009\u00b1\u200918.6 min. Over 4.7 years, survival was 100%, with 1 case of moderate MR recurrence. At follow-up, LVEF improved to 43.04\u2009\u00b1\u20092.26 (P\u2009&amp;lt;\u20090.001), and all patients were NYHA I-II.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>FMRS is a minimally invasive, reproducible technique providing durable repair, symptomatic improvement, and excellent mid-term survival.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivaf187","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T22:14:59Z","timestamp":1755036899000},"source":"Crossref","is-referenced-by-count":0,"title":["Free Margin Running Suture Repair for Bileaflet Mitral Valve Prolapse in Patients with Left Ventricular Dysfunction: A Mid-term Follow-up Study"],"prefix":"10.1093","volume":"40","author":[{"given":"Alfonso","family":"Agnino","sequence":"first","affiliation":[{"name":"Division of Robotic and Minimally Invasive Cardiac Surgery, HUMANITAS Gavazzeni-Castelli , Bergamo, 24125,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5565-0519","authenticated-orcid":false,"given":"Antonio","family":"D\u2019Errico Ramirez","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, CHU Reims, Rue du General Koenig , Reims, 51100,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Parrinello","sequence":"additional","affiliation":[{"name":"Division of Robotic and Minimally Invasive Cardiac Surgery, HUMANITAS Gavazzeni-Castelli , Bergamo, 24125,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6349-0273","authenticated-orcid":false,"given":"Salvatore","family":"Muccio","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, CHU Reims, Rue du General Koenig , Reims, 51100,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amedeo","family":"Anselmi","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Pontchaillou University Hospital , Rennes, 35000,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito Giovanni","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, CHU Reims, Rue du General Koenig , Reims, 51100,","place":["France"]},{"name":"URCA, Universit\u00e9 de Reims Champagne Ardenne , Reims, 51100,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"2025082204413031800_ivaf187-B1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jacc.2020.11.035","article-title":"\"2020 ACC\/AHA guideline for the management of patients with valvular heart 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