{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:40:10Z","timestamp":1760110810202,"version":"build-2065373602"},"reference-count":3,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institutes of Health\/National Heart, Lung, and Blood Institute","award":["R41 HL169059"],"award-info":[{"award-number":["R41 HL169059"]}]},{"name":"Arkansas Children\u2019s Research Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Surgical innovation through first-in-human (FIH) procedures, such as partial heart transplantation, plays an important role in advancing clinical care. However, these procedures frequently proceed without formal ethical oversight. We conducted a systematic PubMed search yielding 48 FIH congenital cardiac case reports (1990\u20132025), then screened each article for 10 predefined oversight-related terms covering regulatory bodies, ethics, and innovation boards. Only 15 procedures (30.6%) documented any oversight language. Although recent innovations demonstrate a modest increase in formal oversight, there remains a paucity of structured review for these novel procedures. These findings highlight persistent gaps in the governance and transparency of high-risk surgical innovation.<\/jats:p>","DOI":"10.1093\/icvts\/ivaf212","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T04:52:18Z","timestamp":1759294338000},"source":"Crossref","is-referenced-by-count":0,"title":["Ethical Oversight of First-in-Human Cardiac Procedures for Congenital Heart Disease in Children"],"prefix":"10.1093","volume":"40","author":[{"given":"Brent K","family":"Winemiller","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Arkansas Children\u2019s Hospital , Little Rock, AR 72202,","place":["United States"]},{"name":"University of Arkansas for Medical Sciences , Little Rock, AR 72202,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua A","family":"Daily","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Arkansas Children\u2019s Hospital , Little Rock, AR 72202,","place":["United States"]},{"name":"University of Arkansas for Medical Sciences , Little Rock, AR 72202,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taufiek K","family":"Rajab","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Arkansas Children\u2019s Hospital , Little Rock, AR 72202,","place":["United States"]},{"name":"University of Arkansas for Medical Sciences , Little Rock, AR 72202,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"volume-title":"The Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects of Research","year":"1979","author":"National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research","key":"2025101011020613700_ivaf212-B1"},{"key":"2025101011020613700_ivaf212-B2","first-page":"E411","article-title":"Reporting of ethics approval and informed consent in clinical case reports and series","volume":"25","author":"Jones","year":"2023","journal-title":"AMA J Ethics"},{"year":"2013","author":"CARE Guidelines","key":"2025101011020613700_ivaf212-B3"}],"container-title":["Interdisciplinary CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivaf212\/64457818\/ivaf212.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/40\/10\/ivaf212\/64457818\/ivaf212.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/40\/10\/ivaf212\/64457818\/ivaf212.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:02:12Z","timestamp":1760108532000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivaf212\/8269467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":3,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,6]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivaf212","relation":{},"ISSN":["2753-670X"],"issn-type":[{"type":"electronic","value":"2753-670X"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,10,1]]},"article-number":"ivaf212"}}