{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:06:16Z","timestamp":1788257176766,"version":"build-2803163510"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Object\u0131ves<\/jats:title>\n                    <jats:p>The arterial switch operation (ASO) is the standard treatment for transposition of the great arteries (TGA), requiring robust myocardial protection due to the neonatal myocardium\u2019s vulnerability to ischaemia. This study compares the myocardial protective efficacy of Custodiol, Del Nido, and cold intermittent blood cardioplegia in neonates undergoing ASO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed 133 neonates with TGA undergoing ASO (2013-2024) at 4 Turkish centres, grouped by cardioplegia: cold blood (n\u2009=\u200947), Custodiol (n\u2009=\u200944), or Del Nido (n\u2009=\u200942). Outcomes included aortic cross-clamp and cardiopulmonary bypass times, troponin I, CK-MB, inotropic support, and ventilation duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Custodiol and Del Nido had shorter cross-clamp (70.4 (8.5) vs 68.7 (7.9) vs 78.2 (9.1)\u2009minutes, P\u2009&amp;lt;\u2009.001) and bypass times (P\u2009=\u2009.004), lower troponin I (4.2 (1.3) vs 4.0 (1.5) vs 6.8 (1.9)\u2009ng\/mL, P\u2009&amp;lt;\u2009.001), reduced inotropic needs (P\u2009&amp;lt;\u2009.001), and shorter ventilation\/intensive care unit stays (P\u2009\u2264\u2009.010). Mortality was similar (P\u2009=\u2009.47).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclus\u0131ons<\/jats:title>\n                    <jats:p>Custodiol and Del Nido cardioplegia strategies provided favourable outcomes compared to cold blood cardioplegia in neonates undergoing ASO, with implications for optimizing myocardial protection protocols in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivaf215","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:49:45Z","timestamp":1758628185000},"source":"Crossref","is-referenced-by-count":1,"title":["Myocardial Protection Efficacy of Custodiol, Del Nido, and Cold Intermittent Blood Cardioplegia in Arterial Switch Operation"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-785X","authenticated-orcid":false,"given":"Mustafa Kemal","family":"Av\u015far","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, \u00c7ukurova University Faculty of Medicine , Adana 01330,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"G\u00fczel","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, \u00c7ukurova University Faculty of Medicine , Adana 01330,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bar\u0131\u015f","family":"K\u0131rat","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Medicana International Istanbul Hospital , Istanbul 34520,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim \u00d6zg\u00fcr","family":"\u00d6nsel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Medicana International Istanbul Hospital , Istanbul 34520,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cenap","family":"Zeybek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Medipol Mega University Hospital , Istanbul 34214,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Yorganc\u0131lar","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medicana International Istanbul Hospital , Istanbul 34520,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lker Kemal","family":"Y\u00fccel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Istanbul University - 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