{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T14:00:33Z","timestamp":1764684033605,"version":"3.46.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is associated with metabolic dysfunctions that accelerate atherosclerosis, posing significant challenges for patients undergoing coronary artery bypass grafting (CABG). In this population, arterial calcification and reduced saphenous vein patency are common complications. This multicentre prospective study aims to evaluate the impact of renal dysfunction on the histological characteristics of arterial and venous grafts used in CABG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Vascular graft specimens collected during CABG were prospectively analysed and stratified into 3 groups based on renal function, according to established publications: Group 1 (glomerular filtration rate [GFR] \u226590 mL\/min\/1.73 m2), Group 2 (GFR 60-89 mL\/min\/1.73 m2), and Group 3 (GFR \u226459 mL\/min\/1.73 m2). Formalin-fixed samples were histologically assessed for intimal thickening (Grade 0-3), fibroelastosis, and vasa vasorum density.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 324 arterial grafts (Group 1: 100; Group 2: 134; Group 3: 90) and 289 vein grafts (Group 1: 86; Group 2: 119; Group 3: 84) were analysed, including 5 arterial and venous grafts from dialysis patients. No significant structural differences were observed between groups. Intimal thickening rates were comparable across renal function stages. Fibroelastosis was more prevalent in venous grafts (56%-64%) than in arterial grafts (10%-15%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study assesses graft histology in CABG patients stratified by renal function. At surgery, CKD does not appear to significantly alter graft structure. Further studies are warranted to explore long-term graft outcomes in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivaf222","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:53:54Z","timestamp":1758628434000},"source":"Crossref","is-referenced-by-count":0,"title":["Histological Analysis of Arterial and Venous Grafts Used in Coronary Bypass for Patients With Renal Insufficiency: A Prospective Multicentre Observational Study"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3251-7659","authenticated-orcid":false,"given":"Valentina","family":"Grazioli","sequence":"first","affiliation":[{"name":"Cardio-Thoracic Surgery Department, Maastricht University Medical Centre , Maastricht, 6229 ER Maastricht,","place":["The Netherlands"]},{"name":"Cardiovascular Research Institute Maastricht (CARIM) , Maastricht, 6229 ER Maastricht,","place":["The Netherlands"]},{"name":"Department of Cardiac Surgery, Humanitas Gavazzeni Clinic , 24125 Bergamo,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-5626","authenticated-orcid":false,"given":"Michele","family":"Di Mauro","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic Surgery Department, Maastricht University Medical Centre , Maastricht, 6229 ER Maastricht,","place":["The Netherlands"]},{"name":"Cardiovascular Research Institute Maastricht (CARIM) , Maastricht, 6229 ER Maastricht,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PierSilvio","family":"Gerometta","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Humanitas Gavazzeni Clinic , 24125 Bergamo,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Parrella","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Cardiovascular and Thoracic Department, Molinette Hospital\u2014Citt\u00e0 della Salute e della Scienza, University of Turin , 10126 Turin,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Matteucci","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Ospedale di Circolo , 21100 Varese,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Musazzi","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Ospedale di Circolo , 21100 Varese,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Cardiovascular and Thoracic Department, Molinette Hospital\u2014Citt\u00e0 della Salute e della Scienza, University of Turin , 10126 Turin,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Sannito","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Humanitas Gavazzeni Clinic , 24125 Bergamo,","place":["Italy"]},{"name":"Division of Cardiac Surgery, Foundation I.R.C.C.S. Policlinico San Matteo , 27100 Pavia,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Panisi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Humanitas Gavazzeni Clinic , 24125 Bergamo,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Agnino","sequence":"additional","affiliation":[{"name":"Division of Robotic and Minimally Invasive Cardiac Surgery, Department of Cardiovascular Surgery, Cliniche Humanitas Gavazzeni , 24125 Bergamo,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Boulos Issa","family":"Sweidan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Unit of Pathology, University of Parma , 43100 Parma,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Guareschi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Unit of Pathology, University of Parma , 43100 Parma,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4680-0815","authenticated-orcid":false,"given":"Mario","family":"Gaudino","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Weill Cornell Medicine, Presbyterian Hospital , NY 10065,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8836-4778","authenticated-orcid":false,"given":"Domenico","family":"Corradi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Unit of Pathology, University of Parma , 43100 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