{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:43:34Z","timestamp":1789037014830,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Although rare, aorto-oesophageal fistula remains one of the most critical diseases in cardiovascular surgery. The lack of prospective studies or large case series leads to an absence of evidence-based therapeutic concepts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of patients treated for aorto-oesophageal fistula between 2014 and 2023. Primary endpoints of analysis were 30-day mortality and median survival; subgroup analysis was performed for aetiology as well as treatment strategy. Additionally, a systematic search was conducted for all studies researching treatment of the disease, including \u22655 patients and published within the last 10 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the collective of 10 patients, 4 manifested as primary fistula, while in 6 patients the fistula occurred secondary to previous thoracic endovascular aortic repair. Median duration to manifestation post-TEVAR was 20.1 months (34.1). Initial treatment consisted of TEVAR or TEVAR-relining in 7 cases, followed by bovine open aortic replacement (n\u2009=\u20091) or partial bovine patch repair (n\u2009=\u20092) when viable. Treatment of the oesophagus consisted of primary suture (n\u2009=\u20091) or oesophagectomy (n\u2009=\u20095) with gastric pull-up or colon interposition. Overall 30-day mortality was 40%, and overall median survival was 7.5 months (12.8). Patients receiving surgical treatment of the oesophagus exhibited longer survival than patients who did not (12.8 months [4.7] vs 0.35 months [0.4]). Across the reviewed literature, the strongest effect on survival originates from surgical treatment of the oesophagus. Specific surgical strategies as well as patient characteristics vary widely.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found TEVAR effective in stabilizing the initial haemorrhage. Short-interval oesophagectomy seems to improve survival and should be considered in most patients. Open aortic replacement with bovine pericardium is a viable option. Interventional treatment options alone do not appear to be sufficient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivaf236","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:18:20Z","timestamp":1760703500000},"source":"Crossref","is-referenced-by-count":3,"title":["Treatment of Aorto-Oesophageal Fistula in a Tertiary German Aortic and Oesophageal Centre A Multidisciplinary Effort"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7289-3448","authenticated-orcid":false,"given":"Felix","family":"Strobl","sequence":"first","affiliation":[{"name":"Abteilung f\u00fcr Gef\u00e4\u00dfchirurgie, Klinikum der Universit\u00e4t M\u00fcnchen , M\u00fcnchen, 81377,","place":["Germany"]},{"name":"Klinik f\u00fcr Gef\u00e4\u00dfchirurgie, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin, 12203,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0013-7870","authenticated-orcid":false,"given":"Jan","family":"Stana","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Gef\u00e4\u00dfchirurgie, Klinikum der Universit\u00e4t M\u00fcnchen , M\u00fcnchen, 81377,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes Klara","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Chirurgie, Charit\u00e9 Universit\u00e4tsmedizin Berlin, CCM|CVK , Berlin, 13353,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldin","family":"Mehmedovic","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Gef\u00e4\u00dfchirurgie, Klinikum der Universit\u00e4t M\u00fcnchen , M\u00fcnchen, 81377,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2903-2490","authenticated-orcid":false,"given":"Maximilian","family":"Pichlmaier","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Herzchirurgie, Klinikum der Universit\u00e4t M\u00fcnchen , M\u00fcnchen, 81377,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert J","family":"Stein","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, Klinikum der Universit\u00e4t M\u00fcnchen , M\u00fcnchen, 81377,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Angele","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, Klinikum der Universit\u00e4t M\u00fcnchen , M\u00fcnchen, 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