{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:39:49Z","timestamp":1760402389513,"version":"build-2065373602"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to determine whether the anatomical burden of prior percutaneous coronary intervention (PCI) influences long-term outcomes after coronary artery bypass grafting, beyond the impact of intervention presence alone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective study analysed consecutive patients undergoing coronary artery bypass grafting at a single institution between 2000 and 2024. The inclusion criteria comprised isolated, non-emergent surgery. Patient categorization was based on prior PCI-treated lesions: none, single, or multiple. The primary end-point was long-term overall survival. The secondary end-points included cardiac death, myocardial infarction, stroke, heart failure hospitalization, and repeat revascularization. Long-term outcomes were assessed using Kaplan-Meier analysis and Cox multivariable models, adjusting for 26 clinical factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 2442 patients, 1205 met the inclusion criteria (755 none, 227 single-lesion, 223 multiple-lesion intervention). Over a median follow-up of 12.0 (interquartile range, 11.3-12.9; maximum: 24.2) years, the multiple-lesion intervention group had higher rates of in-hospital acute kidney injury (34.1% vs 21.1% vs 24.2%, P\u2009=\u2009.003). Overall survival differed significantly between groups over the follow-up period (log-rank P\u2009=\u2009.004), with 15-year survival rates of 35.8%, 46.0%, and 48.0% for multiple-lesion, single-lesion, and no prior PCI groups, respectively. After adjustment, multiple-lesion intervention was associated with increased risks of cardiac death (adjusted subdistribution hazard ratio: 1.91), myocardial infarction (2.26), and repeat revascularization (1.92) compared with no prior intervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Multiple-lesion PCI was associated with higher long-term risks of cardiac death, myocardial infarction, and repeat revascularization, while stroke risk was similar. Single-lesion PCI showed outcomes comparable to no prior PCI except for higher heart failure hospitalization. These findings require confirmation in larger, multicentre comparative studies to address residual confounding.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical registration number<\/jats:title>\n                  <jats:p>4456.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivaf237","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:36:44Z","timestamp":1758987404000},"source":"Crossref","is-referenced-by-count":0,"title":["Anatomical Burden of Prior Percutaneous Coronary Intervention and Long-Term Outcomes After Coronary Artery Bypass Grafting: An Analysis Spanning 2 Decades"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4838-5248","authenticated-orcid":false,"given":"Go","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Kurashiki Central Hospital , Kurashiki, Okayama 710-8602,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4202-8194","authenticated-orcid":false,"given":"Jiro","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Kurashiki Central Hospital , Kurashiki, Okayama 710-8602,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Takauchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Kurashiki Central Hospital , Kurashiki, Okayama 710-8602,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Otani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Kurashiki Central Hospital , Kurashiki, Okayama 710-8602,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoya","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Kurashiki Central Hospital , Kurashiki, Okayama 710-8602,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Kurashiki Central Hospital , Kurashiki, Okayama 710-8602,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6134-0813","authenticated-orcid":false,"given":"Atsushi","family":"Sugaya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Kurashiki Central Hospital , Kurashiki, Okayama 710-8602,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3179-1055","authenticated-orcid":false,"given":"Shingo","family":"Hirao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Kurashiki Central Hospital , Kurashiki, Okayama 710-8602,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-6724","authenticated-orcid":false,"given":"Tatsuhiko","family":"Komiya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Kurashiki Central Hospital , Kurashiki, Okayama 710-8602,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,27]]},"reference":[{"key":"2025101309012877500_ivaf237-B1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/ejcts\/ezy289","article-title":"2018 ESC\/EACTS guidelines on myocardial revascularization","volume":"55","author":"Sousa-Uva","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"2025101309012877500_ivaf237-B2","article-title":"Virani SS, Newby LK, Arnold SV, et al. 2023 AHA\/ACC\/ACCP\/ASPC\/NLA\/PCNA guideline for the management of Patients With Chronic Coronary Disease: A report of the American heart association\/American college of cardiology joint committee on clinical practice guidelines. Circulation. 2023;148:e9-e119."},{"key":"2025101309012877500_ivaf237-B3","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.athoracsur.2009.05.053","article-title":"The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 1\u2014coronary artery bypass grafting surgery","volume":"88","author":"Shahian","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"2025101309012877500_ivaf237-B4","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.athoracsur.2018.03.003","article-title":"Adult cardiac surgery risk models: part 2-statistical methods and results","volume":"105","author":"O\u2019Brien","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"2025101309012877500_ivaf237-B5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.athoracsur.2016.10.028","article-title":"Previous percutaneous coronary intervention does not increase adverse events after coronary artery bypass surgery","volume":"104","author":"Ueki","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"2025101309012877500_ivaf237-B6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/icvts\/ivu449","article-title":"Influence of previous percutaneous coronary intervention on clinical outcome of coronary artery bypass grafting: a meta-analysis of comparative studies\u2020","volume":"20","author":"Ueki","year":"2015","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2025101309012877500_ivaf237-B7","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/j.athoracsur.2014.12.073","article-title":"Coronary artery bypass grafting after percutaneous intervention has higher early mortality: a meta-analysis","volume":"99","author":"Altarabsheh","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"2025101309012877500_ivaf237-B8","doi-asserted-by":"crossref","first-page":"20406223221078755","DOI":"10.1177\/20406223221078755","article-title":"Prior percutaneous coronary intervention and outcomes in patients after coronary artery bypass grafting: a meta-analysis of 308,284 patients","volume":"13","author":"Zhang","year":"2022","journal-title":"Ther Adv Chronic Dis"},{"key":"2025101309012877500_ivaf237-B9","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1093\/ejcts\/ezab198","article-title":"Multiple percutaneous coronary interventions may negatively impact cardiac remodelling after bypass surgery","volume":"60","author":"Nonaka","year":"2021","journal-title":"Eur J Cardiothorac Surg"},{"key":"2025101309012877500_ivaf237-B10","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.106.685313","article-title":"Clinical end points in coronary stent trials: a case for standardized definitions","volume":"115","author":"Cutlip","year":"2007","journal-title":"Circulation"},{"author":"Summary of recommendation statements","key":"2025101309012877500_ivaf237-B11"},{"key":"2025101309012877500_ivaf237-B12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0003-4975(00)01436-3","article-title":"Skeletonization and harvest of the internal thoracic artery with an ultrasonic scalpel","volume":"70","author":"Higami","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"2025101309012877500_ivaf237-B13","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.jtcvs.2015.07.027","article-title":"The no-touch saphenous vein for coronary artery bypass grafting maintains a patency, after 16 years, comparable to the left internal thoracic artery: a randomized trial","volume":"150","author":"Samano","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025101309012877500_ivaf237-B14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.amjcard.2020.12.076","article-title":"Comparison of outcomes of percutaneous coronary intervention versus coronary artery bypass grafting among patients with three-vessel coronary artery disease in the new-generation drug-eluting stents era (from CREDO-Kyoto PCI\/CABG registry cohort-3)","volume":"145","author":"Matsumura-Nakano","year":"2021","journal-title":"Am J Cardiol"},{"key":"2025101309012877500_ivaf237-B15","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/S0003-4975(03)00872-5","article-title":"Coronary artery and myocardial inflammatory reaction induced by intracoronary stent","volume":"76","author":"Gomes","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"2025101309012877500_ivaf237-B16","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jtcvs.2021.05.052","article-title":"Postcardiac surgery myocardial ischemia: why, when, and how to intervene","volume":"165","author":"Robinson","year":"2023","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Interdisciplinary CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivaf237\/64418544\/ivaf237.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/40\/10\/ivaf237\/64418544\/ivaf237.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/40\/10\/ivaf237\/64418544\/ivaf237.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:34:17Z","timestamp":1760362457000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivaf237\/8266881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,27]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,6]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivaf237","relation":{},"ISSN":["2753-670X"],"issn-type":[{"type":"electronic","value":"2753-670X"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,27]]},"article-number":"ivaf237"}}