{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T21:46:29Z","timestamp":1763415989985,"version":"3.45.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the extent of pleural inflammation and fibrosis induced by autologous blood vs talc pleurodesis in an exploratory experimental model and evaluate effects of postoperative non-steroidal anti-inflammatory analgesics on pleurodesis formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-eight Sprague Dawley rats underwent intrapleural instillation of autologous blood on one side and talc on the contralateral side. They were sacrificed at 2, 4, 6, 15, or 30 days for macroscopic and histopathological analysis. Eight animals in the late euthanasia groups received oral Ibuprofen postoperatively. A pathologist, who was blinded to the interventions assessed all animals for macroscopic adhesions in the chest as well as microscopic evaluation for inflammation and fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found no significant differences between autologous blood and talc regarding macroscopic adhesion scores, or grading of inflammation and fibrosis. The inflammatory response peaked earlier after autologous blood compared with talc. Fibrosis progressively increased after both interventions. Ibuprofen reduced inflammation and fibrosis in both types of pleurodesis. Statistically significant reductions in fibrosis were seen after 15 days in the talc group (P\u2009=\u2009.008) and after 30 days in the autologous blood group (P\u2009=\u2009.024).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Autologous blood and talc pleurodesis induce comparable inflammatory responses and fibrosis in this experimental model suggesting that the mechanism of autologous blood patch for prolonged air leakage is not just a mechanical plug effect. Ibuprofen reduced all inflammatory responses after both interventions suggesting that non-steroidal anti-inflammatory drugs may impair pleurodesis formation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivaf264","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:14:20Z","timestamp":1761830060000},"source":"Crossref","is-referenced-by-count":0,"title":["Autologous Blood Versus Talc Pleurodesis and the Influence of Non-steroidal Anti-inflammatory Drugs"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2929-3073","authenticated-orcid":false,"given":"Finn Amundsen","family":"Dittberner","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Odense University Hospital , Odense 5000,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana Moreano","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Odense University Hospital , Odense 5000,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars Svend","family":"B\u00f6rnsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Odense University Hospital , Odense 5000,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1270-8068","authenticated-orcid":false,"given":"Peter Bj\u00f8rn","family":"Licht","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Odense University Hospital , Odense 5000,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"2025111716413407300_ivaf264-B1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chest.2017.02.020","article-title":"Management of persistent air leaks","volume":"152","author":"Dugan","year":"2017","journal-title":"Chest"},{"key":"2025111716413407300_ivaf264-B2","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0003-4975(99)00160-5","article-title":"Pleurodesis by autologous blood, doxycycline, and talc in a rabbit model","volume":"67","author":"Mitchem","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"2025111716413407300_ivaf264-B3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jss.2009.01.027","article-title":"Autologous blood pleurodesis in rats to elucidate the amounts of blood required for reliable and reproducible results","volume":"161","author":"Ozpolat","year":"2010","journal-title":"J Surg Res"},{"key":"2025111716413407300_ivaf264-B4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12890-020-01260-1","article-title":"Comparison of hydroxyethyl starch 130\/0.4 (6%) with commonly used agents in an experimental pleurodesis model","volume":"20","author":"Kapicibasi","year":"2020","journal-title":"BMC Pulm Med"},{"key":"2025111716413407300_ivaf264-B5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.5606\/tgkdc.dergisi.2019.17544","article-title":"Non-steroid anti-inflammatory drugs reduce the efficacy of autologous blood pleurodesis","volume":"27","author":"Yalcinkaya","year":"2019","journal-title":"Turk Gogus Kalp Damar Cerrahisi Derg"},{"key":"2025111716413407300_ivaf264-B6","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.athoracsur.2009.12.012","article-title":"Incidence and risk factors of persistent air leak after major pulmonary resection and use of chemical pleurodesis","volume":"89","author":"Liberman","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"2025111716413407300_ivaf264-B7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/crj.12509","article-title":"Outcome of pleurodesis using different agents in management prolonged air leakage following lung resection","volume":"12","author":"Jablonski","year":"2018","journal-title":"Clin Respir J"},{"key":"2025111716413407300_ivaf264-B8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5761\/atcs.oa.23-00115","article-title":"A comparison of the efficacies of OK-432 and talc slurry for pleurodesis in patients with prolonged air leak after pulmonary resection","volume":"30","author":"Watanabe","year":"2024","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"2025111716413407300_ivaf264-B9","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s11748-020-01534-9","article-title":"Negative impact of chemical pleurodesis on postoperative pulmonary function for managing prolonged air leakage after segmentectomy","volume":"69","author":"Maeyashiki","year":"2021","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"2025111716413407300_ivaf264-B10","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1111\/1759-7714.14138","article-title":"Autologous blood pleurodesis for the treatment of postoperative air leaks. 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