{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:48:52Z","timestamp":1787960932159,"version":"build-2784847793"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A nuclear protein in testis (NUT) carcinoma is a rare, aggressive malignancy often diagnosed late due to non-specific symptoms and low awareness. A 69-year-old woman presented with haemoptysis and a positron emission tomography-avid lung nodule (cT1N0M0). An initial bronchoscopic biopsy suggested small cell carcinoma with negative NUT staining. Following a lobectomy, immunohistochemical analysis showed strong nuclear NUT positivity, and fluorescence in situ hybridization confirmed NUT rearrangement. This case was atypical due to the patient\u2019s age, early stage, and initial misdiagnosis from a limited biopsy. The non-specific presentation of an NUT carcinoma requires a high degree of suspicion, and small biopsies risk a misdiagnosis.<\/jats:p>","DOI":"10.1093\/icvts\/ivaf278","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:49:13Z","timestamp":1764679753000},"source":"Crossref","is-referenced-by-count":1,"title":["An Early-Stage Nuclear Protein in Testis Carcinoma of the Lung in an Older Woman"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2993-5817","authenticated-orcid":false,"given":"Guangyao","family":"Shan","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhongshan Hospital, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"2026012304315791400_ivaf278-B1","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1158\/0008-5472.CAN-23-2545","article-title":"The BRD4-NUT fusion alone drives malignant transformation of NUT carcinoma","volume":"83","author":"Durall","year":"2023","journal-title":"Cancer Res"},{"key":"2026012304315791400_ivaf278-B2","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1158\/1078-0432.CCR-12-1153","article-title":"Clinicopathologic features and long-term outcomes of NUT midline carcinoma","volume":"18","author":"Bauer","year":"2012","journal-title":"Clin Cancer Res"},{"key":"2026012304315791400_ivaf278-B3","doi-asserted-by":"crossref","first-page":"pkz094","DOI":"10.1093\/jncics\/pkz094","article-title":"An anatomical site and genetic-based prognostic model for patients with nuclear protein in testis (NUT) midline carcinoma: analysis of 124 patients","volume":"4","author":"Chau","year":"2020","journal-title":"JNCI Cancer Spectr"},{"key":"2026012304315791400_ivaf278-B4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.lungcan.2015.10.001","article-title":"NUT carcinoma of the thorax: case report and review of the literature","volume":"90","author":"Harms","year":"2015","journal-title":"Lung Cancer"},{"key":"2026012304315791400_ivaf278-B5","doi-asserted-by":"crossref","first-page":"1497124","DOI":"10.3389\/fimmu.2025.1497124","article-title":"Pulmonary NUT carcinoma, an elusive and refractory entity, shows transient response to chemotherapeutics and PD-1 inhibitor: a case report and literature review","volume":"16","author":"Yang","year":"2025","journal-title":"Front Immunol"}],"container-title":["Interdisciplinary CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivaf278\/65730124\/ivaf278.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/41\/1\/ivaf278\/65730124\/ivaf278.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/41\/1\/ivaf278\/65730124\/ivaf278.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:32:06Z","timestamp":1769160726000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivaf278\/8364028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivaf278","relation":{},"ISSN":["2753-670X"],"issn-type":[{"value":"2753-670X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,12,3]]},"article-number":"ivaf278"}}