{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:14:15Z","timestamp":1772212455126,"version":"3.50.1"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This case report presents an instance of pleural epithelioid hemangioendothelioma (EHE), a vascular tumour with an incidence of less than 1% among vascular tumors. The patient, a 43-year-old man, presented with a right-sided pleural effusion, longstanding neck and shoulder pain, and worsening pleuritic chest pain. Initial imaging revealed a left infra-clavicular soft tissue mass, pleural thickening, and pulmonary nodules suggestive of metastases. Despite inconclusive initial biopsies, immunohistochemistry and an international pathology review confirmed EHE, characterized by CAMTA1 expression and WWTR1 CAMTA1 fusion. The pleural involvement indicated metastatic disease, leading to a poor prognosis. Treatment with the MEK inhibitor trametinib was initiated, but the patient died within 3 months. This case underscores the diagnostic challenges of EHE due to its rarity and variable clinical presentation, which often delays diagnosis until advanced stages. The report highlights the aggressive nature of pleural EHE and the lack of standardized treatments, emphasizing the need for early recognition.<\/jats:p>","DOI":"10.1093\/icvts\/ivaf286","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:44:30Z","timestamp":1769690670000},"source":"Crossref","is-referenced-by-count":0,"title":["One in One Million\u2014A Case of Pleural Disease"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-7417","authenticated-orcid":false,"given":"Tara","family":"Byrne","sequence":"first","affiliation":[{"name":"Cardiothoracic Department, Galway University Hospital , Galway,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvie","family":"Blaskova","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Galway University Hospital , Galway,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Soo","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department, Galway University Hospital , Galway,","place":["Ireland"]},{"name":"Medical Oncology Department, Galway University Hospital , Galway,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"2026022711164675200_ivaf286-B1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.4081\/oncol.2014.259","article-title":"Epithelioid hemangioendothelioma: an overview and update on a rare vascular tumor","volume":"8","author":"Sardaro","year":"2014","journal-title":"Oncol Rev"},{"key":"2026022711164675200_ivaf286-B2","doi-asserted-by":"publisher","first-page":"100170","DOI":"10.1016\/j.esmoop.2021.100170","article-title":"Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts","volume":"6","author":"Stacchiotti","year":"2021","journal-title":"ESMO Open"},{"key":"2026022711164675200_ivaf286-B3","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1378\/chest.11-0039","article-title":"Clinical patterns and outcome in epithelioid hemangioendothelioma with or without pulmonary involvement: insights from an internet registry in the study of a rare cancer","volume":"140","author":"Lau","year":"2011","journal-title":"Chest"},{"key":"2026022711164675200_ivaf286-B4","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41379-019-0368-8","article-title":"Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets","volume":"33","author":"Rosenbaum","year":"2020","journal-title":"Mod Pathol"},{"key":"2026022711164675200_ivaf286-B5","author":"European Society for Medical Oncology (ESMO)","year":"2023"}],"container-title":["Interdisciplinary CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivaf286\/66709575\/ivaf286.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/41\/2\/ivaf286\/66709575\/ivaf286.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/41\/2\/ivaf286\/66709575\/ivaf286.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:16:55Z","timestamp":1772209015000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivaf286\/8455048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,5]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivaf286","relation":{},"ISSN":["2753-670X"],"issn-type":[{"value":"2753-670X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,2]]},"article-number":"ivaf286"}}