{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:34:35Z","timestamp":1778254475826,"version":"3.51.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the feasibility and early clinical outcomes of transcatheter valve replacement in high-surgical-risk patients with carcinoid heart disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This study included 15 procedures performed in 9 patients with symptomatic carcinoid heart disease between 2021 and 2025. Valve involvement included the pulmonary valve in 9 cases, the tricuspid valve in 5 cases, and the aortic valve in 1 case. Valve selection (SAPIEN 3, TOPAZ, LUX) was individualized according to anatomical considerations. All 9 patients received intravenous periprocedural octreotide. Outcomes included procedural success, NYHA class, and echocardiographic evaluation of valve and ventricular function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Single-valve replacement was performed in 4 patients (2 pulmonary and 2 tricuspid). Double-valve replacement involving the pulmonary and tricuspid valves was performed in 4 patients, and 1 patient underwent triple-valve replacement (aortic, pulmonary, and tricuspid). One high-risk patient required conversion after a tricuspid procedure but ultimately recovered after a prolonged hospital stay. At a median follow-up of 9.9\u202fmonths (IQR 3.5), all patients showed clinical improvement. One patient developed a transient tricuspid paravalvular thrombus without dysfunction or clinical consequence. Echocardiography demonstrated a reduction in right ventricular diameter. No case of endocarditis was observed. One patient died 4\u202fmonths post-procedure from tumour progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This first series of transcatheter valve replacements in carcinoid heart disease suggests that a complete percutaneous approach is feasible, safe, and potentially beneficial. These early results warrant confirmation in larger cohorts with longer follow-up and may represent a paradigm shift in the management of carcinoid valve disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivag001","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:39:35Z","timestamp":1767789575000},"source":"Crossref","is-referenced-by-count":2,"title":["Transcatheter Valve Replacement in Carcinoid Heart Disease: A\u00a0Potential Change of Paradigm"],"prefix":"10.1093","volume":"41","author":[{"given":"Marie-Anne","family":"Barbier","sequence":"first","affiliation":[{"name":"H\u00f4pital Cardiologique Louis PRADEL, Universit\u00e9 Claude Brenard LYON1, Hospices Civils de LYON, Lyon 69000, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gerard","sequence":"additional","affiliation":[{"name":"H\u00f4pital Edouard HERIOT, Universit\u00e9 Claude Brenard LYON1, Hospices Civils de LYON, Lyon 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