{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:03:22Z","timestamp":1770818602704,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"key project of Henan Province medical science and technology research","award":["SBGJ202102206"],"award-info":[{"award-number":["SBGJ202102206"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the application of a mechanical side-to-side oesophagogastric anastomosis in the reconstruction of the digestive tract of beagles after an oesophagectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighteen beagles were randomly divided into 3 groups: the hand-sewn (HS) group, the linear-stapled anastomosis in the oesophagus and anterior portion of the stomach (LESA) group and the linear-stapled anastomosis in the oesophagus and the posterior portion of the stomach (LESP) group. The gastro-oesophageal reflux, anastomotic area, anastomotic bursting pressure and the breaking strength in the beagles at 1 week and 12 weeks after the operations were compared. The histopathological morphology was observed using haematoxylin-eosin staining and Masson staining, and the expression of the vascular endothelial growth factor (VEGF) was detected by immunohistochemical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 1 and 12 weeks after the operation, the percentage of gastro-oesophageal reflux time and the longest reflux time in the HS group and the LESP group were higher than those in the LESA group (P\u2009&amp;lt;\u2009.05). The anastomotic areas in the HS group were significantly smaller than those in the LESA and LESP groups at 1 and 12 weeks postoperatively (P\u2009&amp;lt;\u2009.05); there were no differences in the anastomotic areas in the LESA and LESP groups. At 1 and 12 weeks postoperatively, the bursting pressure and breaking strength of the anastomosis, the collagen-fibre area ratio and VEGF positive expression in the LESA group were significantly higher than those in the HS group (P\u2009&amp;lt;\u2009.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The mechanical side-to-side oesophagogastric anastomosis of the oesophagus and the anterior wall of the stomach can reduce the occurrence of gastro-oesophageal reflux, increase the bursting pressure and breaking strength, promote collagen fibre and VEGF expression, to promote healing of the anastomosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivag010","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:39:59Z","timestamp":1767875999000},"source":"Crossref","is-referenced-by-count":0,"title":["The Application of a Mechanical Side-to-Side Oesophagogastric Anastomosis in the Reconstruction of the Digestive Tract After an Oesophagectomy in a Beagle Model"],"prefix":"10.1093","volume":"41","author":[{"given":"Gao-Feng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, The 988th Hospital of PLA Joint Logistics Support , Zhengzhou, Henan Province 450042,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The 988th Hospital of PLA Joint Logistics Support , Zhengzhou, Henan Province 450042,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Juan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The 988th Hospital of PLA Joint Logistics Support , Zhengzhou, Henan Province 450042,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The 988th Hospital of PLA Joint Logistics Support , Zhengzhou, Henan Province 450042,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The 988th Hospital of PLA Joint Logistics Support , Zhengzhou, Henan Province 450042,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The 988th Hospital of PLA Joint Logistics Support , Zhengzhou, Henan Province 450042,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ling","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The 988th Hospital of PLA Joint Logistics Support , Zhengzhou, Henan Province 450042,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4959-7776","authenticated-orcid":false,"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The 988th Hospital of PLA Joint Logistics Support , Zhengzhou, Henan Province 450042,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"2026021107564910000_ivag010-B1","article-title":"Minimally invasive esophagectomy","volume":"2021","author":"Dziodzio","year":"2021","journal-title":"Multimed Man Cardiothorac Surg"},{"key":"2026021107564910000_ivag010-B2","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.jtcvs.2020.04.018","article-title":"Commentary: practice makes perfect in cervical esophagogastric anastomosis","volume":"160","author":"Panda","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026021107564910000_ivag010-B3","doi-asserted-by":"crossref","first-page":"544","DOI":"10.21037\/jgo-23-166","article-title":"Clinical analysis of tubular stapler-assisted nested anastomosis in the prevention of postoperative esophageal cancer complications","volume":"14","author":"Ma","year":"2023","journal-title":"J Gastrointest Oncol"},{"key":"2026021107564910000_ivag010-B4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00423-024-03290-3","article-title":"Fashioning esophagogastric anastomosis in robotic Ivor-Lewis esophagectomy: a multicenter experience","volume":"409","author":"Milone","year":"2024","journal-title":"Langenbecks Arch Surg"},{"key":"2026021107564910000_ivag010-B5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1097\/SLE.0000000000001050","article-title":"Transthoracic esophagectomy: hand-sewn versus side-to-side linear-stapled versus circular-stapled anastomosis: a systematic review and meta-analysis","volume":"32","author":"Schlottmann","year":"2022","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"2026021107564910000_ivag010-B6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/ags3.12220","article-title":"Comparison of the modified collard and hand-sewn anastomosis for cervical esophagogastric anastomosis after esophagectomy in esophageal cancer patients: a propensity score-matched analysis","volume":"3","author":"Sugimura","year":"2019","journal-title":"Ann Gastroenterol Surg"},{"key":"2026021107564910000_ivag010-B7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s12876-020-01393-x","article-title":"Comparison of end-to-side hand-sewn and side-to-side stapled cervical esophagogastric anastomosis in patients with lower thoracic esophageal cancer undergoing transhiatal esophagectomy: an Iranian Retrospective Cohort Study","volume":"20","author":"Rasihashemi","year":"2020","journal-title":"BMC Gastroenterol"},{"key":"2026021107564910000_ivag010-B8","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/icvts\/ivaa065","article-title":"Semimechanical anastomosis during oesophagectomy reduces leaks and stenosis: a propensity score matched analysis","volume":"31","author":"Mazza","year":"2020","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2026021107564910000_ivag010-B9","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1007\/s00423-022-02706-2","article-title":"Linear- versus circular-stapled esophagogastric anastomosis during esophagectomy: systematic review and meta-analysis","volume":"407","author":"Aiolfi","year":"2022","journal-title":"Langenbecks Arch Surg"},{"key":"2026021107564910000_ivag010-B10","doi-asserted-by":"crossref","DOI":"10.1093\/dote\/doac073","article-title":"Real-life introduction of powered circular stapler for esophagogastric anastomosis: cohort and propensity matched score study","volume":"36","author":"Vanstraelen","year":"2023","journal-title":"Dis Esophagus"},{"key":"2026021107564910000_ivag010-B11","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1007\/s00268-023-07050-0","article-title":"Fully robotic side-to-side linear-stapled anastomosis during robotic Ivor Lewis esophagectomy","volume":"47","author":"Guerra","year":"2023","journal-title":"World J Surg"},{"key":"2026021107564910000_ivag010-B12","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s11605-022-05482-y","article-title":"Which anastomotic techniques is the best choice for cervical esophagogastric anastomosis in esophagectomy? A Bayesian network meta-analysis","volume":"27","author":"Chen","year":"2023","journal-title":"J Gastrointest Surg"},{"key":"2026021107564910000_ivag010-B13","doi-asserted-by":"crossref","first-page":"907","DOI":"10.21037\/atm.2020.03.66","article-title":"Progress in the esophagogastric anastomosis and the challenges of minimally invasive thoracoscopic surgery","volume":"9","author":"Bonavina","year":"2021","journal-title":"Ann Transl Med"},{"key":"2026021107564910000_ivag010-B14","first-page":"1743","article-title":"Comparative analysis of the clinical efficacy of two different methods of digestive tract reconstruction and anastomosis in thoracoscopic and laparoscopic esophagectomy for esophageal cancer","volume":"30","author":"Wang","year":"2023","journal-title":"Chin J Clin Thorac Cardiov Surg"},{"key":"2026021107564910000_ivag010-B15","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s00268-011-0955-4","article-title":"Is there any benefit to incorporating a laparoscopic procedure into minimally invasive esophagectomy? The impact on perioperative results in patients with esophageal cancer","volume":"35","author":"Lee","year":"2011","journal-title":"World J Surg"},{"key":"2026021107564910000_ivag010-B16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1442-2050.2010.01113.x","article-title":"Minimally invasive esophagectomy versus open esophagectomy, a symptom assessment study","volume":"24","author":"Mehran","year":"2011","journal-title":"Dis Esophagus"},{"key":"2026021107564910000_ivag010-B17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1590\/1806-9282.67.01.20200354","article-title":"Importance of esophageal pH monitoring and manometry in indicating surgical treatment of gastroesophageal reflux disease","volume":"67","author":"Alves","year":"2021","journal-title":"Rev Assoc Med Bras (1992)"},{"key":"2026021107564910000_ivag010-B18","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.3748\/wjg.15.3183","article-title":"Improved quality of life in patients with gastric cancer after esophagogastrostomy reconstruction","volume":"15","author":"Zhang","year":"2009","journal-title":"World J Gastroenterol"},{"key":"2026021107564910000_ivag010-B19","doi-asserted-by":"crossref","first-page":"8258096","DOI":"10.1155\/2018\/8258096","article-title":"Influence of early postoperative feeding in gastrointestinal anastomotic fistula formation and healing time in rabbits","volume":"2018","author":"Tang","year":"2018","journal-title":"Biomed Res Int"},{"key":"2026021107564910000_ivag010-B20","doi-asserted-by":"crossref","first-page":"316","DOI":"10.14744\/tjtes.2024.39551","article-title":"Effect of pre-incisional and peritoneal local anesthetics administration on Colon anastomosis and wound healing","volume":"30","author":"Kesici","year":"2024","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"2026021107564910000_ivag010-B21","doi-asserted-by":"crossref","first-page":"213152","DOI":"10.1016\/j.bioadv.2022.213152","article-title":"Collagen fabricated delivery systems for wound healing: a new roadmap","volume":"142","author":"Gajbhiye","year":"2022","journal-title":"Biomater Adv"},{"key":"2026021107564910000_ivag010-B22","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.21037\/jtd-24-427","article-title":"The relationship between the collagen score at the anastomotic site of esophageal squamous cell carcinoma and anastomotic leakage","volume":"16","author":"Chen","year":"2024","journal-title":"J Thorac Dis"},{"key":"2026021107564910000_ivag010-B23","first-page":"3217","article-title":"Allogenic multilayered fibroblast sheets promote anastomotic site healing in a rat model of esophageal reconstruction","volume":"15","author":"Yamamoto","year":"2023","journal-title":"Am J Transl Res"},{"key":"2026021107564910000_ivag010-B24","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/jcb.30344","article-title":"Molecular mechanism of VEGF and its role in pathological angiogenesis","volume":"123","author":"Ahmad","year":"2022","journal-title":"J Cell Biochem"},{"key":"2026021107564910000_ivag010-B25","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ciresp.2017.08.008","article-title":"Histopathological and immunohistochemical analysis of the use of collagen dressing as a reinforcement of esophagic anastomosis in a rat experimental model","volume":"95","author":"Garcia-Perez","year":"2017","journal-title":"Cir Esp"},{"key":"2026021107564910000_ivag010-B26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5090\/jcs.20.146","article-title":"Experimental tracheal replacement: angiogenesis and null apoptosis promote stenosis","volume":"54","author":"Santib\u00e1\u00f1ez-Salgado","year":"2021","journal-title":"J Chest Surg"}],"container-title":["Interdisciplinary CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivag010\/66313658\/ivag010.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/41\/2\/ivag010\/66313658\/ivag010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/41\/2\/ivag010\/66313658\/ivag010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:57:03Z","timestamp":1770814623000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivag010\/8417673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,5]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivag010","relation":{},"ISSN":["2753-670X"],"issn-type":[{"value":"2753-670X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,1,8]]},"article-number":"ivag010"}}