{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T14:17:31Z","timestamp":1771597051690,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japan Agency for Medical Research and Development under grant","award":["JP22mk0101179"],"award-info":[{"award-number":["JP22mk0101179"]}]},{"name":"Japan Agency for Medical Research and Development under grant","award":["JP24he2302011h0202"],"award-info":[{"award-number":["JP24he2302011h0202"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Conventional annuloplasty rings used in mitral valve repair (MVr) are made of metal or synthetic polymers, which may increase infection risk. This study aimed to develop a mitral annuloplasty ring using decellularized tissue and evaluate its ability to suppress regurgitation in a degenerative mitral regurgitation (DMR) model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 4\u2009mm diameter annuloplasty ring was created using decellularized bovine tendon. Porcine mitral valve complexes (including the annulus, leaflets, chordae tendineae, and papillary muscles) were obtained from a slaughterhouse. The annulus was enlarged by 4\u2009mm, and the 2 chordae tendineae of the posterior leaflet (P2) were severed. The DMR model, integrated into a pulsatile flow simulator, was repaired using a commercial\u2014Physio II, Colvin-Galloway (CG) Future, Tailor band, and a decellularized tendon-based ring. Regurgitation control and effective mitral valve area (MVA) were compared (n\u2009=\u20096 for each group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The regurgitation rate of the DMR model was 52.3\u2009\u00b1\u20093.4%, consistent with severe MR. Post-MVr with each ring, the regurgitation rates were 14.9\u2009\u00b1\u20093.1% (Physio II), 14.5\u2009\u00b1\u20091.1% (CG Future), 16.4\u2009\u00b1\u20091.7% (Tailor band), and 15.5\u2009\u00b1\u20093.0% (decellularized tendon-based biological ring). All of these rates were significantly reduced, with no significant differences among them. Effective MVA was comparable across groups: 2.46\u2009\u00b1\u20090.28\u2009cm2 (Physio II), 2.33\u2009\u00b1\u20090.54\u2009cm2 (CG Future), 2.28\u2009\u00b1\u20090.12\u2009cm2 (Tailor band), and 2.27\u2009\u00b1\u20090.53\u2009cm2 (decellularized tendon-based biological ring).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The decellularized tendon-based annuloplasty ring demonstrated functional performance comparable to that of current mitral annuloplasty devices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivag040","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:30:42Z","timestamp":1770121842000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of a Decellularized Tendon-Based Mitral Annuloplasty Ring on Regurgitation Suppression in Degenerative Mitral Regurgitation Model: An\n                    <i>In Vitro<\/i>\n                    Pulsatile Circulation Study"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0751-0192","authenticated-orcid":false,"given":"Ikuo","family":"Katayama","sequence":"first","affiliation":[{"name":"Cooperative Major in Advanced Biomedical Sciences, Graduate School of Advanced Science and Engineering, Waseda University , Tokyo 162-8480,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Imai","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Biomedical Sciences, Graduate School of Advanced Science and Engineering, Waseda University , Tokyo 162-8480,","place":["Japan"]},{"name":"Department of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, Waseda University , Tokyo 162-8480,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusei","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Modern Mechanical Engineering, Graduate School of Creative Science and Engineering, Waseda University , Tokyo 169-8555,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3994-5509","authenticated-orcid":false,"given":"Kiyotaka","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Biomedical Sciences, Graduate School of Advanced Science and Engineering, Waseda University , Tokyo 162-8480,","place":["Japan"]},{"name":"Department of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, Waseda University , Tokyo 162-8480,","place":["Japan"]},{"name":"Department of Modern Mechanical Engineering, Graduate School of Creative Science and Engineering, Waseda University , Tokyo 169-8555,","place":["Japan"]},{"name":"Institute for Medical Regulatory Science, Waseda University , Tokyo 162-8480,","place":["Japan"]},{"name":"Waseda Research Institute for Science and Engineering, Waseda University , Tokyo 169-8555,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"2026022008464375000_ivag040-B1","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0140-6736(18)30473-2","article-title":"Outcome and undertreatment of mitral regurgitation: a community cohort study","volume":"391","author":"Dziadzko","year":"2018","journal-title":"Lancet"},{"key":"2026022008464375000_ivag040-B2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0002-9149(98)01064-9","article-title":"Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart 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