{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:52:15Z","timestamp":1781632335818,"version":"3.54.5"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":68,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Uniportal video-assisted thoracoscopic surgery (U-VATS) has been increasingly adopted for anatomical segmentectomy because of its minimally invasive nature and favourable recovery profile. However, whether perioperative outcomes differ between complex and simple segmentectomy when performed via U-VATS remains uncertain. This study compared perioperative outcomes between complex and simple U-VATS segmentectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta-analysis were conducted according to PRISMA 2020 and AMSTAR 2 guidelines, and the study was registered in PROSPERO (CRD420251151464). Six databases were searched for studies comparing complex and simple U-VATS segmentectomy for pulmonary lesions. Primary outcomes were operative time, intraoperative blood loss, and conversion to thoracotomy. Secondary outcomes included chest tube duration, hospital stay, and postoperative complications. Random-effects models were used for pooled analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five retrospective studies, including 1051 patients (707 complex; 344 simple), were analysed. No statistically significant differences were detected in operative time (MD\u2009=\u200915.25\u2009min, 95% CI: \u22121.25 to 31.75; P\u2009=\u2009.07; I2\u2009=\u200988%), intraoperative blood loss (MD\u2009=\u2009\u22121.33\u2009mL, 95% CI: \u221211.95 to 9.29; P\u2009=\u2009.81; I2\u2009=\u200958%), or conversion to thoracotomy (OR\u2009=\u20090.46, 95% CI: 0.10-1.99; P\u2009=\u2009.30; I2\u2009=\u20090%). Secondary outcomes also showed no significant differences, including chest tube duration (MD\u2009=\u2009\u22120.15\u2009days, 95% CI: \u22120.41 to 0.11; P\u2009=\u2009.25; I2\u2009= 26%), hospital stay (MD\u2009=\u2009\u22120.16\u2009days, 95% CI: \u22120.73 to 0.40; P\u2009=\u2009.57; I2\u2009= 66%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No statistically significant differences were detected in key perioperative outcomes between complex and simple U-VATS segmentectomy; however, given substantial clinical heterogeneity and limited retrospective evidence, findings should be interpreted cautiously and are most applicable to selected patients treated in experienced, high-volume centres.<\/jats:p>\n                  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Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3531-9997","authenticated-orcid":false,"given":"Samuel","family":"Heuts","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center Department of Cardiothoracic Surgery, , Maastricht, Limburg, 6229 HX,","place":["The Netherlands"]},{"name":"Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Department of Cardiothoracic Surgery, , Maastricht, Limburg, 6229 ER,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5514-5297","authenticated-orcid":false,"given":"Setu","family":"Gupta","sequence":"additional","affiliation":[{"name":"Brunel University London Brunel Medical School, , London, England, UB8 3PH,","place":["United 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