{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:54:55Z","timestamp":1781826895399,"version":"3.54.5"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Sutureless aortic valve prostheses reduce surgical times and facilitate minimally invasive approaches, improving patient outcomes. However, it remains unclear whether these devices provide specific benefits to female patients, in whom sex-related differences in valve surgery outcomes remain a matter of debate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Up to September 2024, 535 subjects (261 women) received Perceval Plus at 35 investigational sites from Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting observational prospective registry. Moreover, meta-regression was performed to assess whether sex modifies outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Men have a larger body size (body surface area: male 2.0\u2009\u00b1\u20090.2 vs female 1.8\u2009\u00b1\u20090.2, P\u2009&amp;lt;\u2009.001), resulting in a larger prosthesis size (size S: male 2.9% vs female 34.9%). Surgery was still significantly faster in women (cross-clamp time: male 63.7\u2009\u00b1\u200929.4 min vs female 56.8\u2009\u00b1\u200929.4 min, P\u2009=\u2009.002), partly because approximately 10% of procedures in male patients were combined, increasing duration. Early outcomes were comparable between sexes (hospital deaths: male 3 [1.1%] vs female 5 [1.9%], P\u2009=\u2009.49). At follow-up, no significant differences were observed (follow-up deaths: male 9 [3.3%] vs female 5 [1.9%], P\u2009=\u2009.42). Meta-regression showed no effect of female sex prevalence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our registry and meta-regression analysis did not reveal significant differences in outcomes between men and women. Preoperative characteristics, however, differ between sexes and may influence outcomes and prosthesis choice. Long-term conclusions are limited by the current follow-up duration and will be further explored as data collection progresses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical registration number<\/jats:title>\n                    <jats:p>NCT05002543, ClinicalTrials.gov (https:\/\/clinicaltrials.gov\/study\/NCT05002543)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivag170","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:36:20Z","timestamp":1780400180000},"source":"Crossref","is-referenced-by-count":0,"title":["Sex-Related Outcome After Sutureless Aortic Valve Replacement With Perceval Plus: Results From a Global Registry and Meta-Regression"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-9834","authenticated-orcid":false,"given":"Giuseppe","family":"Santarpino","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Magna Graecia University , Catanzaro 88100,","place":["Italy"]},{"name":"Department of Cardiac Surgery, Citt\u00e0 di Lecce Hospital , Lecce 73100,","place":["Italy"]},{"name":"Department of Cardiac Surgery, Paracelsus Medical University , Nuremberg 90419,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Heart and Vascular Centre, Maastricht University Medical Centre , Maastricht 6229 HX,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-5626","authenticated-orcid":false,"given":"Michele","family":"Di Mauro","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia , Foggia 71122,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"D\u2019Anna","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Citt\u00e0 di Lecce Hospital , Lecce 73100,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5785-4416","authenticated-orcid":false,"given":"Chiara Maria","family":"Prencipe","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Magna Graecia University , Catanzaro 88100,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Voisine","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Universit\u00e9 Laval , Quebec G1V 0A6,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Bisleri","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, St. Michael\u2019s Hospital , Toronto M5B 1W8,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Parrino","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Ochsner Clinic Foundation , New Orleans, LA 70121,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bates","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, East Carolina University , Greenville, NC 27858,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Chad","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Duke University , Durham, NC 27708,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Roselli","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Cleveland Clinic , Cleveland, OH 44195,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-332X","authenticated-orcid":false,"given":"Cristian","family":"Baeza","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospitals Cleveland Medical Center , Cleveland, OH 44195,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Heimansohn","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, St. Vincent Heart Center of Indiana , Indianapolis, IN 46290,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Bov\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, UZ Gent , Gent 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