{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:03:32Z","timestamp":1785225812764,"version":"3.55.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dokkyo Medical University Alumni Association Research Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated whether systolic flow-based indices derived from four-dimensional flow magnetic resonance imaging (4D flow MRI) can predict early aortic enlargement in patients with uncomplicated type B aortic dissection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-centre observational cohort study included 36 patients with uncomplicated type B aortic dissection between 2015 and 2025 who underwent 4D flow MRI a median of 42 days after onset with serial computed tomography (CT) follow-up. Aortic growth rates were calculated using ordinary least squares regression over the first year. False lumen (FL) flow index, FL gross flow, true lumen gross flow, and FL flow range were analysed. Correlations with aortic growth rate and group comparisons between patients with and without CT-defined aortic progression were assessed using Spearman\u2019s rank correlation and the Mann-Whitney U test. Exploratory multivariable logistic regression adjusted for baseline maximum aortic diameter was also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen patients (44%) met CT-based aortic progression criteria; 15 (42%) underwent thoracic endovascular aortic repair within 1 year. Conventional CT-derived anatomical predictors were similar between the progression and stable groups. The FL flow index (\u03c1\u2009=\u20090.44; 95% CI, 0.11-0.70) and FL gross flow (\u03c1\u2009=\u20090.46; 95% CI, 0.13-0.69) showed moderate positive correlations with aortic growth rate. On multivariable analysis, the FL flow index remained associated with progression (odds ratio, 2.31; 95% CI, 1.04-5.13) after adjustment for baseline maximum aortic diameter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These hypothesis-generating findings suggest that systolic FL-dominant flow may complement CT morphology in identifying patients at risk of early aortic progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivag198","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:44:18Z","timestamp":1783424658000},"source":"Crossref","is-referenced-by-count":0,"title":["Haemodynamic Predictors of Early Aortic Growth in Uncomplicated Type B Dissection: A Cohort Study"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1307-2164","authenticated-orcid":false,"given":"Yusuke","family":"Takei","sequence":"first","affiliation":[{"name":"Department of Cardiac and Vascular Surgery, Dokkyo Medical University School of Medicine , Mibu, Tochigi 321-0293,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Cardio Flow Design Inc. , Chiyoda, Tokyo 102-0082,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Cardio Flow Design Inc. , Chiyoda, Tokyo 102-0082,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Cardio Flow Design Inc. , Chiyoda, Tokyo 102-0082,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Fundamental Education Premedical Sciences, Dokkyo Medical University , Mibu, Tochigi 321-0293,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4017-8503","authenticated-orcid":false,"given":"Ikuko","family":"Shibasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Iwaki City Medical Center , Iwaki, Fukushima 973-8555,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2837-0227","authenticated-orcid":false,"given":"Masahiro","family":"Tezuka","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Surgery, Dokkyo Medical University School of Medicine , Mibu, Tochigi 321-0293,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Surgery, Dokkyo Medical University School of Medicine , Mibu, Tochigi 321-0293,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Surgery, Dokkyo Medical University School of Medicine , Mibu, Tochigi 321-0293,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Surgery, Dokkyo Medical University School of Medicine , Mibu, Tochigi 321-0293,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Surgery, Dokkyo Medical University School of Medicine , Mibu, Tochigi 321-0293,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7585-0945","authenticated-orcid":false,"given":"Hirotsugu","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Surgery, Dokkyo Medical University School of Medicine , Mibu, Tochigi 321-0293,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"2026072803563359400_ivag198-B1","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1161\/CIRCULATIONAHA.117.031264","article-title":"Insights from the international registry of acute aortic dissection: a 20-year experience of collaborative clinical 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