{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:51:38Z","timestamp":1791953498912,"version":"4.3.4"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tumour-to-tumour metastasis (TTM) is a very rare condition in which a malignant tumour (donor) metastasizes into another primary neoplasm, either benign or malignant (recipient). We report the case of a 74-year-old man previously surgically treated for a clear cell renal cell carcinoma (ccRCC) who developed a new subsolid nodule in the right upper pulmonary lobe discovered at a 4-year follow-up CT scan. The patient underwent a right uniportal thoracoscopic S1 segmentectomy and mediastinal lymph node dissection. Histopathological examination revealed a lung adenocarcinoma (LUAD) containing a focus of metastatic ccRCC without lymph node involvement or evidence of additional metastatic disease. To date, the patient remains disease-free. Metastasis of renal tumour cells into a primary lung tumour is exceptionally rare. To our knowledge, this is the first reported case of ccRCC metastasizing into LUAD without evidence of systemic dissemination.<\/jats:p>","DOI":"10.1093\/icvts\/ivag201","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:18:32Z","timestamp":1787926712000},"source":"Crossref","is-referenced-by-count":0,"title":["Tumour-to-Tumour Metastasis: A Rare Case of Clear Cell Renal Cell Carcinoma Metastasizing Into Lung Adenocarcinoma"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2788-1657","authenticated-orcid":false,"given":"Valerio","family":"Sebastianelli","sequence":"first","affiliation":[{"name":"Department of General and Specialized Surgery and Anesthesiology, University of Rome Sapienza Thoracic Surgery Unit, , 00161 Rome,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"De Maria","sequence":"additional","affiliation":[{"name":"Department of General and Specialized Surgery and Anesthesiology, University of Rome Sapienza Thoracic Surgery Unit, , 00161 Rome,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7066-7896","authenticated-orcid":false,"given":"Paolo","family":"Graziano","sequence":"additional","affiliation":[{"name":"Department of Radiological, Oncological and Pathological Sciences, University of Rome Sapienza, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-4535","authenticated-orcid":false,"given":"Marco","family":"Anile","sequence":"additional","affiliation":[{"name":"Department of Radiological, Oncological and Pathological Sciences, University of Rome Sapienza, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"2026101400414921200_ivag201-B1","first-page":"406","article-title":"Seltene metastasenbildung","volume":"13","author":"Berent","year":"1902","journal-title":"Zbl Allg Path Anat"},{"key":"2026101400414921200_ivag201-B2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/1097-0142(196809)22:3<635::AID-CNCR2820220320>3.0.CO;2-O","article-title":"Metastases of cancer to cancer","volume":"22","author":"Campbell","year":"1968","journal-title":"Cancer"},{"issue":"2","key":"2026101400414921200_ivag201-B3","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S1055-3207(18)30064-4","article-title":"Seed and soil revisited","volume":"10","author":"Fidler","year":"2001","journal-title":"Surg Oncol Clin North Am"},{"key":"2026101400414921200_ivag201-B4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s10585-025-10332-7","article-title":"Tumor-to-tumor metastases: systematic review and meta-analysis of 685 reported cases","volume":"42","author":"Kunc","year":"2025","journal-title":"Clin Exp Metastasis"},{"key":"2026101400414921200_ivag201-B5","doi-asserted-by":"publisher","first-page":"e932012","DOI":"10.12659\/AJCR.932012","article-title":"Tumor-to-tumor metastasis: lung adenocarcinoma as a recipient of metastasis from renal cell carcinoma: a case report","volume":"22","author":"Caballero","year":"2021","journal-title":"Am J Case Rep."}],"container-title":["Interdisciplinary CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivag201\/70828337\/ivag201.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/41\/10\/ivag201\/70828337\/ivag201.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/article-pdf\/41\/10\/ivag201\/70828337\/ivag201.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:42:10Z","timestamp":1791952930000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/doi\/10.1093\/icvts\/ivag201\/8772369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":5,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivag201","relation":{},"ISSN":["2753-670X"],"issn-type":[{"value":"2753-670X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,8,28]]},"article-number":"ivag201"}}