{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T17:32:26Z","timestamp":1786469546461,"version":"build-2736575974"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cardiopulmonary bypass (CPB) priming may influence haemodilution, bleeding, and end-organ injury during HeartMate 3 (HM3) implantation, but evidence in contemporary left ventricular assist device (LVAD) surgery is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed 92 HM3 implantations (2015-2025) by priming strategy (blood-based [FFP\u2009+\u2009RBC], n\u2009=\u200936; crystalloid, n\u2009=\u200956). The primary end-point was postoperative right heart failure (RHF; Interagency Registry for Mechanically Assisted Circulatory Support [INTERMACS]). Multivariable regression and propensity score-based inverse probability of treatment weighting (IPTW) sensitivity analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline characteristics were balanced between groups, with comparable age (blood-based: 58 [49.5-66.0]; crystalloid: 62 [55.8-68.2]; P\u2009=\u2009.069) and female sex (blood-based: n\u2009=\u20093\/36 [8.3%]; crystalloid: n\u2009=\u20098\/56 [14.3%]; P\u2009=\u2009.518). Right heart failure was lower with blood-based priming (blood-based: n\u2009=\u20093\/36 [8.3%]; crystalloid: n\u2009=\u200917\/56 [30.4%]; P\u2009=\u2009.012; adjusted OR 0.23 [95% confidence interval (CI) 0.06-0.86]; P\u2009=\u2009.030). Dialysis was lower unadjusted (blood-based: n\u2009=\u20094\/36 [11.1%]; crystalloid: n\u2009=\u200918\/56 [32.1%]; P\u2009=\u2009.021), with a directionally lower adjusted estimate (OR 0.30 [95% CI, 0.09-1.01]; P\u2009=\u2009.053). Delirium was lower with blood-based priming (blood-based: n\u2009=\u20093\/36 [8.3%]; crystalloid: n\u2009=\u200916\/56 [28.6%]; P\u2009=\u2009.019; adjusted OR 0.22 [95% CI, 0.06-0.84]; P\u2009=\u2009.027). Survival did not differ significantly (log-rank P\u2009=\u2009.055; adjusted HR 0.59 [95% CI, 0.27-1.32]; P\u2009=\u2009.201). IPTW analyses showed lower delirium (OR 0.23 [95% CI, 0.06-0.84]) and an attenuated RHF association (OR 0.35 [95% CI, 0.10-1.23]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Blood-based CPB priming was associated with lower RHF and delirium, and directionally lower dialysis rates, after HM3 implantation. Survival estimates were not statistically significant. Findings require prospective validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical registration number<\/jats:title>\n                    <jats:p>Ethics Committee of the Medical Faculty of RWTH Aachen (EK 25-154).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivag216","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:43:45Z","timestamp":1785498225000},"source":"Crossref","is-referenced-by-count":0,"title":["Blood-Based Versus Crystalloid Cardiopulmonary Bypass Priming in Left Ventricular Assist Device Surgery: Impact on End-Organ Function and Survival"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9560-6512","authenticated-orcid":false,"given":"Sophie","family":"Bonni","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital RWTH Aachen , Aachen 52074,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-8743","authenticated-orcid":false,"given":"Rashad","family":"Zayat","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital RWTH Aachen , Aachen 52074,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasja W M","family":"Ramnath","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital RWTH Aachen , Aachen 52074,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4466-9959","authenticated-orcid":false,"given":"Nima","family":"Hatam","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital RWTH Aachen , Aachen 52074,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lachmandath","family":"Tewarie","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital RWTH Aachen , Aachen 52074,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Moza","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital RWTH Aachen , Aachen 52074,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolijn C","family":"Sales","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital RWTH Aachen , Aachen 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