{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:25:15Z","timestamp":1793773515145,"version":"4.6.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20OC0065584"],"award-info":[{"award-number":["NNF20OC0065584"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mitral valve repair using patch materials is frequently limited by degeneration, inflammation, and calcification, particularly in younger patients. This study evaluated the feasibility and functional durability of a partially resorbable hybrid warp-knitted bioscaffold (Synfolium, Teijin Medical Technologies, Osaka, Japan) for mitral reconstruction in a growing porcine model. In a 6-month-old Danish Landrace pig (80 kg), the mitral A2 segment was replaced with a 10\u2009\u00d7\u200930 mm Synfolium patch via left thoracotomy. Postoperative echocardiography demonstrated normal valve function. After 181 days, echocardiography was repeated prior to sacrifice, followed by macroscopic inspection, histological analysis, and high-resolution micro-computed tomography (micro-CT) of the explanted valve. During follow-up, the animal grew to 159 kg. Six-month echocardiography demonstrated preserved valve function with minimal regurgitation despite a 62% increase in annular diameter. Macroscopically, the patch was fully integrated and endothelialized, with no signs of structural failure. Histology demonstrated low-grade chronic inflammation confined to suture interfaces, with no fibrosis or inflammation within the patch matrix. No calcification was identified on histology or micro-CT. In this growing porcine model, mitral leaflet reconstruction using a Synfolium patch preserved valve competence and resisted calcification over 6 months despite substantial cardiac growth. These findings are encouraging, although repetition of the study is required to confirm the results.<\/jats:p>","DOI":"10.1093\/icvts\/ivag229","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:47:42Z","timestamp":1789127262000},"source":"Crossref","is-referenced-by-count":0,"title":["Repair of the Anterior Mitral Leaflet in a Growing Porcine Model Using a Partially Resorbable Knitted Patch"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-9117","authenticated-orcid":false,"given":"J H","family":"Jedrzejczyk","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University , Aarhus 8200,","place":["Denmark"]},{"name":"Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital , Aarhus 8200,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hazekamp","sequence":"additional","affiliation":[{"name":"Department of 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